Effects of ethanol on CYP2E1 levels and related oxidative stress using a standard balanced diet

Effects of ethanol on CYP2E1 levels and related oxidative stress using a standard balanced diet

Author Azzalis, Ligia A. Google Scholar
Fonseca, Fernando L. A. Google Scholar
Simon, Karin A. Google Scholar
Schindler, Fernanda Google Scholar
Giavarotti, Leandro Google Scholar
Monteiro, Hugo P. Autor UNIFESP Google Scholar
Videla, Luis A. Google Scholar
Junqueira, Virginia B. C. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fac Med ABC
Univ Anhembi Morumbi
Univ Chile
Abstract Expression of cytochrome P4502E1 (CYP2E1) is very much influenced by nutritional factors, especially carbohydrate consumption, and various results concerning the expression of CYP2E1 were obtained with a low-carbohydrate diet. This study describes the effects of ethanol treatment on CYP2E1 levels and its relationship with oxidative stress using a balanced standard diet to avoid low or high carbohydrate consumption. Rats were fed for 1, 2, 3, or 4 weeks a commercial diet plus an ethanol-sucrose solution. the results have shown that ethanol administration was associated with CYP2E1 induction and stabilization without related oxidative stress. Our findings suggest that experimental models with a low-carbohydrate/high-fat diet produce some undesirable CYP2E1 changes that are not present when a balanced standard diet is given.
Keywords Cytochrome P4502E1
ethanol
standard diet
oxidative stress
rat liver
Language English
Date 2012-07-01
Published in Drug and Chemical Toxicology. London: Informa Healthcare, v. 35, n. 3, p. 324-329, 2012.
ISSN 0148-0545 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 324-329
Origin http://dx.doi.org/10.3109/01480545.2011.619192
Access rights Closed access
Type Article
Web of Science ID WOS:000305539000014
URI http://repositorio.unifesp.br/handle/11600/35084

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