Chronobiology: Relevance for tuberculosis

Chronobiology: Relevance for tuberculosis

Author Santos, Ligia Gabrielle Google Scholar
Pires, Gabriel Natan Autor UNIFESP Google Scholar
Azeredo Bittencourt, Lia Rita Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Inst Pesquisas Biol
Abstract Despite the knowledge concerning the pathogenesis of tuberculosis, this disease remains one of the most important causes of mortality worldwide. Several risk factors are well-known, such poverty, HIV infection, and poor nutrition, among others. However, some issues that may influence tuberculosis warrant further investigation. in particular, the chronobiological aspects related to tuberculosis have garnered limited attention. in general, the interface between tuberculosis and chronobiology is manifested in four ways: variations in vitamin D bioavailability, winter conditions, associated infections, and circannual oscillations of lymphocytes activity. Moreover, tuberculosis is related to the following chronobiological factors: seasonality, latitude, photoperiod and radiation. Despite the relevance of these topics, the relationship between them has been weakly reviewed. This review aims to synthesize the studies regarding the association between tuberculosis and chronobiology, as well as urge critical discussion and highlight its applicability to health policies for tuberculosis. (C) 2012 Elsevier B.V. All rights reserved.
Keywords Chronobiology
Infectious diseases
Vitamin D
Language English
Sponsor AFIP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 98/14303-3
Date 2012-07-01
Published in Tuberculosis. Edinburgh: Churchill Livingstone, v. 92, n. 4, p. 293-300, 2012.
ISSN 1472-9792 (Sherpa/Romeo, impact factor)
Publisher Churchill Livingstone
Extent 293-300
Access rights Closed access
Type Review
Web of Science ID WOS:000305270900004

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