Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease

Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease

Author Payão, Spencer Luiz Marques Autor UNIFESP Google Scholar
Gonçalves, Gisela Moraes Google Scholar
Lábio, Roger Willian de Google Scholar
Horiguchi, Lie Google Scholar
Mizumoto, Igor Google Scholar
Rasmussen, Lucas Trevizani Autor UNIFESP Google Scholar
Pinhel, Marcela Augusta de Souza Google Scholar
Souza, Dorotéia Rossi Silva Google Scholar
Bechara, Marcelo Dib Google Scholar
Chen, Elizabeth Suchi Autor UNIFESP Google Scholar
Mazzotti, Diego Robles Autor UNIFESP Google Scholar
Bertolucci, Paulo Henrique Ferreira Autor UNIFESP Google Scholar
Smith, Marilia de Arruda Cardoso Autor UNIFESP Google Scholar
Institution USC
Universidade Federal de São Paulo (UNIFESP)
Fac Med Marilia FAMEMA
Fac Med Sao Jose do Rio Preto
Univ Marilia UNIMAR
Abstract Our study aimed to associate IL-1 beta and IL-1RN polyrnorphisms with AD disease in comparison with elderly control group from São Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and -511C>T and -31T>C (IL-1 beta) polymorphisms. Our findings revealed that -511C/-31T/2-repetitions VNTR haplotype had a protective effect for AD when compared to EC (p=0.005), whereas -511C/-31C/1-repetition VNTR haplotype was associated as a risk factor for AD (p=0.021). Taken together, we may suggest that there is a relevant role of IL-1 genes cluster in AD pathogenesis in this Brazilian population. (c) 2012 Elsevier B.V. All rights reserved.
Keywords Alzheimer's disease
Interleukin-1 beta
Polymorphisms
Haplotypes
Receptor antagonist
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Universidade do Sagrado Coracao de Bauru
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Faculdade de Medicina de Marilia (FAMEMA)
Grant number FAPESP: 06/07240-3
FAPESP: 09/15857-9
FAPESP: 04/15273-3
Date 2012-06-15
Published in Journal of Neuroimmunology. Amsterdam: Elsevier B.V., v. 247, n. 1-2, p. 59-62, 2012.
ISSN 0165-5728 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 59-62
Origin http://dx.doi.org/10.1016/j.jneuroim.2012.03.012
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000304792900008
URI http://repositorio.unifesp.br/handle/11600/34995

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