The effects of high-intensity resistance exercise on the blood lipid profile and liver function in hypercholesterolemic hamsters

The effects of high-intensity resistance exercise on the blood lipid profile and liver function in hypercholesterolemic hamsters

Author Trevisan Frajacomo, Fernando Tadeu Google Scholar
Piva Demarzo, Marcelo Marcos Autor UNIFESP Google Scholar
Fernandes, Cleverson Rodrigues Google Scholar
Martinello, Flavia Google Scholar
Bachur, José Alexandre Google Scholar
Uyemura, Sergio Akira Google Scholar
Andrade Perez, Sergio Eduardo de Google Scholar
Garcia, Sergio Britto Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Santa Catarina (UFSC)
Universidade Federal de São Carlos (UFSCar)
Abstract It is well established that atherogenic dyslipidemia, characterized by high levels of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein (LDL) cholesterol and low levels of high-density lipoprotein (HDL) cholesterol, constitutes important risk factors for cardiovascular disease. Regular exercise has been associated with a reduced risk for metabolic diseases. However, studies supporting the concept that resistance exercise is a modifier of blood lipid parameters are often contradictory. the aim of this study was to investigate the effects of high-intensity resistance exercise on the serum levels of TG, TC, HDL and non-HDL cholesterol, glucose, and the liver function enzymes alanine aminotransferase (ALT, EC 2.6.1.2) and aspartate aminotransferase (AST, EC 2.6.1.1) in golden Syrian hamsters (Mesocricetus auratus (Waterhouse, 1839)) fed a hypercholesterolemic diet. Sedentary groups (S) and exercise groups (E) were fed a standard diet (SS and ES) or a cholesterol-enriched diet (standard plus 1% cholesterol, SC and EC). Resistance exercise was performed by jumps in the water, carrying a load strapped to the chest, representing 10 maximum repetitions (10 RM, 30 s rest, five days per week for five weeks). Mean blood sample comparisons were made by ANOVA + Tukey or ANOVA + Kruskal-Wallis tests (p < 0.05) to compare parametric and nonparametric samples, respectively. There were no differences in blood lipids between the standard diet groups (SS and ES) (p > 0.05). However, the EC group increased the glucose, non-HDL, and TC levels in comparison with the ES group. Moreover, the EC group increased the TG levels versus the SC group (p < 0.05). in addition, the ALT levels were increased only by diet treatment. These findings indicated that high-intensity resistance exercise contributed to dyslipidemia in hamsters fed a hypercholesterolemic diet, whereas liver function enzymes did not differ in regards to the exercise protocol.
Keywords cholesterol
lipid profile
liver function
resistance exercise
exercise intensity
hypercholesterolemic hamsters
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
University of São Paulo
Date 2012-06-01
Published in Applied Physiology Nutrition and Metabolism-physiologie Appliquee Nutrition Et Metabolisme. Ottawa: Canadian Science Publishing, Nrc Research Press, v. 37, n. 3, p. 448-454, 2012.
ISSN 1715-5312 (Sherpa/Romeo, impact factor)
Publisher Canadian Science Publishing, Nrc Research Press
Extent 448-454
Origin http://dx.doi.org/10.1139/H2012-008
Access rights Closed access
Type Article
Web of Science ID WOS:000303657900006
URI http://repositorio.unifesp.br/handle/11600/34981

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