Social behavior impairment in offspring exposed to maternal seizures in utero

Social behavior impairment in offspring exposed to maternal seizures in utero

Author Novaes, Gisane Faria Google Scholar
Amado, Debora Autor UNIFESP Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Cysneiros, Roberta Monterazzo Google Scholar
Institution UPM
Universidade Federal de São Paulo (UNIFESP)
Abstract Human and animal models have demonstrated that maternal seizures in utero could be deleterious to the development of the offspring. This study focused on the social behavior of offspring exposed to seizures in utero. A pilocarpine model of temporal lobe epilepsy was induced in female Wistar rats that were mated after the first spontaneous seizure. Early after birth, pups from an epileptic mother were reared by a control mother. To evaluate the influence of the adoption process, two other groups were added: rat pups from control mothers cross-fostered with other control mothers, and rat pups reared by their birth mother. Animals exposed to seizures in utero showed impaired social behavior with no signs of anxiety-like behavior. This study demonstrated that epileptic seizures during pregnancy could be harmful to brain development and may increase the risk of developing neurodevelopmental disorders. the mechanisms underlying the abnormalities of social behavior are not well understood, and further studies in this field are warranted.
Keywords Epilepsy
Pregnancy
Social interaction
Anxiety
Language English
Sponsor MACKPESQUISA
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2012-06-01
Published in Journal of Neural Transmission. Wien: Springer Wien, v. 119, n. 6, p. 639-644, 2012.
ISSN 0300-9564 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 639-644
Origin http://dx.doi.org/10.1007/s00702-011-0751-1
Access rights Closed access
Type Article
Web of Science ID WOS:000304462400002
URI http://repositorio.unifesp.br/handle/11600/34938

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