Cytokines in schizophrenia: Possible role of anti-inflammatory medications in clinical and preclinical stages

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dc.contributor.author Mansur, Rodrigo Barbachan [UNIFESP]
dc.contributor.author Zugman, Andre [UNIFESP]
dc.contributor.author Asevedo, Elson de Miranda [UNIFESP]
dc.contributor.author Cunha, Graccielle Rodrigues da [UNIFESP]
dc.contributor.author Bressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.author Brietzke, Elisa [UNIFESP]
dc.date.accessioned 2016-01-24T14:27:16Z
dc.date.available 2016-01-24T14:27:16Z
dc.date.issued 2012-06-01
dc.identifier http://dx.doi.org/10.1111/j.1440-1819.2012.02354.x
dc.identifier.citation Psychiatry and Clinical Neurosciences. Hoboken: Wiley-Blackwell, v. 66, n. 4, p. 247-260, 2012.
dc.identifier.issn 1323-1316
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34916
dc.description.abstract Aims: in this paper, we review the literature on the efficacy of anti-inflammatory agents as neuroprotectors in clinical and preclinical stages of schizophrenia. Method: A synthetic and integrative approach was applied to review studies stemming from epidemiology, phenomenology, cognition, genetics and neuroimaging data. We provide conclusions and future directions of research on early-onset schizophrenia. Results: Abnormal inflammatory activation has been demonstrated in schizophrenia. Increases or imbalances in cytokines before birth or during childhood may impact neurodevelopment and produce vulnerability to schizophrenia. the specificity of inflammatory abnormalities in psychiatric disorders is controversial. Similar increases in pro-inflammatory cytokines have been described in other disorders, especially mood and anxiety disorders. One of the most important challenges at this point is the understanding of neurobiological correlates of prodromal stages of schizophrenia. Conclusion: Although future research should investigate the exact role of different cytokines in pathophysiology of schizophrenia, these mediators emerge as promising molecular targets to its prevention and treatment. en
dc.format.extent 247-260
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Psychiatry and Clinical Neurosciences
dc.rights Acesso aberto
dc.subject anti-inflammatory en
dc.subject inflammation en
dc.subject neuroplasticity en
dc.subject prodrome en
dc.subject schizophrenia en
dc.title Cytokines in schizophrenia: Possible role of anti-inflammatory medications in clinical and preclinical stages en
dc.type Resenha
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Program Recognit & Intervent Individuals Risk Men, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Interdisciplinary Lab Clin Neurosci LINC, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Program Recognit & Intervent Individuals Risk Men, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Interdisciplinary Lab Clin Neurosci LINC, Dept Psychiat, São Paulo, Brazil
dc.identifier.doi 10.1111/j.1440-1819.2012.02354.x
dc.description.source Web of Science
dc.identifier.wos WOS:000304438800001



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