Cytokines in schizophrenia: Possible role of anti-inflammatory medications in clinical and preclinical stages

Cytokines in schizophrenia: Possible role of anti-inflammatory medications in clinical and preclinical stages

Author Mansur, Rodrigo Barbachan Autor UNIFESP Google Scholar
Zugman, Andre Autor UNIFESP Google Scholar
Asevedo, Elson de Miranda Autor UNIFESP Google Scholar
Cunha, Graccielle Rodrigues da Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Aims: in this paper, we review the literature on the efficacy of anti-inflammatory agents as neuroprotectors in clinical and preclinical stages of schizophrenia. Method: A synthetic and integrative approach was applied to review studies stemming from epidemiology, phenomenology, cognition, genetics and neuroimaging data. We provide conclusions and future directions of research on early-onset schizophrenia. Results: Abnormal inflammatory activation has been demonstrated in schizophrenia. Increases or imbalances in cytokines before birth or during childhood may impact neurodevelopment and produce vulnerability to schizophrenia. the specificity of inflammatory abnormalities in psychiatric disorders is controversial. Similar increases in pro-inflammatory cytokines have been described in other disorders, especially mood and anxiety disorders. One of the most important challenges at this point is the understanding of neurobiological correlates of prodromal stages of schizophrenia. Conclusion: Although future research should investigate the exact role of different cytokines in pathophysiology of schizophrenia, these mediators emerge as promising molecular targets to its prevention and treatment.
Keywords anti-inflammatory
inflammation
neuroplasticity
prodrome
schizophrenia
Language English
Date 2012-06-01
Published in Psychiatry and Clinical Neurosciences. Hoboken: Wiley-Blackwell, v. 66, n. 4, p. 247-260, 2012.
ISSN 1323-1316 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 247-260
Origin http://dx.doi.org/10.1111/j.1440-1819.2012.02354.x
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000304438800001
URI http://repositorio.unifesp.br/handle/11600/34916

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