Acute and short-term effect of an extra dose of formoterol in COPD patients

Show simple item record Studart, Fernando Sérgio [UNIFESP] Izbicki, Meyer [UNIFESP] Nery, Luiz Eduardo [UNIFESP] Oliveira, Luis Vicente Franco Donner, Claudio F. Jardim, José Roberto [UNIFESP] Nascimento, Oliver Augusto [UNIFESP] 2016-01-24T14:27:16Z 2016-01-24T14:27:16Z 2012-06-01
dc.identifier.citation Respiratory Medicine. London: W B Saunders Co Ltd, v. 106, n. 6, p. 853-860, 2012.
dc.identifier.issn 0954-6111
dc.description.abstract Rationale: Formoterol action may decrease progressively after its inhalation. It is unknown if this decrease of bronchodilation following formoterol use could be associated with worsening hyperinflation.Objectives: To investigate whether the use of an extra daily dose of formoterol could promote a greater reduction in lung hyperinflation and a greater improvement in inspiratory capacity (IC) compared to usual doses.Methods: 56 hyperinflated COPD patients were divided into two groups: F2 and F3. Basal evaluation was carried out after 5 days of formoterol washout. in order to evaluate the acute effect, spirometry and body plethysmography were performed 8 h after the first formoterol dose in both groups and repeated 1 h after an additional formoterol dose (F3) or placebo (F2). the short-term effect was evaluated by measuring the resting lung function after a 14-day period of formoterol t.i.d. (F3) or formoterol b.i.d. + placebo (F2).Measurements and main results: A second formoterol dose inhaled 8 h after the previous dose promoted additional improvements in lung function, as demonstrated by higher IC (118 +/- 140 mL, p < 0.001) and tower functional residual capacity (FRC) (-383 +/- 367 mL, p <0.001). On day 15, the mean differences from baseline regarding all lung function variables were similar between the groups.Conclusion: An extra daily dose of formoterol inhaled 8 h after a previous dose could result in an acute additional peak of bronchodilation. However, short-term formoterol t.i.d. showed no advantages over formoterol b.i.d. concerning reduction of hyperinflation in resting lung function. (C) 2012 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Mantecorp Pharmaceutical Company(R)
dc.format.extent 853-860
dc.language.iso eng
dc.publisher W B Saunders Co Ltd
dc.relation.ispartof Respiratory Medicine
dc.rights Acesso aberto
dc.subject COPD en
dc.subject Formoterol en
dc.subject Hyperinflation en
dc.title Acute and short-term effect of an extra dose of formoterol in COPD patients en
dc.type Artigo
dc.contributor.institution Mondo Med Multidisciplinary & Rehabil Outpatient
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Nove Julho Univ
dc.description.affiliation Mondo Med Multidisciplinary & Rehabil Outpatient, I-28021 Borgomanero, NO, Italy
dc.description.affiliation Universidade Federal de São Paulo, Div Resp, São Paulo, Brazil
dc.description.affiliation Nove Julho Univ, Rehabil Sci Masters Program Dept, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Resp, São Paulo, Brazil
dc.identifier.file WOS000303429700012.pdf
dc.identifier.doi 10.1016/j.rmed.2011.12.015
dc.description.source Web of Science
dc.identifier.wos WOS:000303429700012


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