Biperiden (M-1 antagonist) impairs the expression of cocaine conditioned place preference but potentiates the expression of cocaine-induced behavioral sensitization

Biperiden (M-1 antagonist) impairs the expression of cocaine conditioned place preference but potentiates the expression of cocaine-induced behavioral sensitization

Author Ramos, Anna C. Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Oliveira, Maria G. M. Autor UNIFESP Google Scholar
Soeiro, Aline C. Autor UNIFESP Google Scholar
Galduroz, Jose C. F. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Cocaine addiction is a public health issue in many countries, stressing the need for more effective treatments. As all drugs of abuse, cocaine acts on the brain reward system, increasing dopamine (DA) levels. Other neurotransmitters such as acetylcholine (ACh) are involved in the mechanisms underlying the development and the maintenance of cocaine addiction. ACh plays an important role in learning and memory processes and also regulates DA in some specific regions of the central nervous system. the present study investigated the effects of biperiden, a muscarinic cholinergic (mACh) antagonist in two animal models: conditioned place preference (CPP) and behavioral sensitization. Male C57BL/6J mice were used in both studies. the CPP protocol was unbiased and carried out in three phases: habituation, conditioning and testing. for conditioning, cocaine was injected at a dose of 10 mg/kg in eight 15 min-sessions. the treatment with biperiden (doses of 0.1, 1 and 10 mg/kg) was made 30 min prior to the testing session. for behavioral sensitization development, cocaine was administered at the dose of 10 mg/kg for 10 days. After sensitization, two challenges were performed: saline and cocaine (5 mg/kg). Biperiden (10 mg/kg) was administered 30 min before the cocaine challenge. At the dose of 10 mg/kg, biperiden blocked the cocaine-CPP expression, suggesting an effect on conditioned memory retrieval. However, the same dose potentiated the expression of behavioral sensitization, suggesting an increase in DA release, probably in the NAc. Biperiden, as other mACh antagonists, may be a promising drug for the pharmacologic treatment of cocaine addiction. (C) 2012 Elsevier B.V. All rights reserved.
Keywords Acetylcholine
Behavioral sensitization
Biperiden
Cocaine
Conditioned place preference
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2012-05-16
Published in Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 231, n. 1, p. 213-216, 2012.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 213-216
Origin http://dx.doi.org/10.1016/j.bbr.2012.03.030
Access rights Closed access
Type Article
Web of Science ID WOS:000304024900027
URI http://repositorio.unifesp.br/handle/11600/34897

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account