Low-level laser therapy improves repair following complete resection of the sciatic nerve in rats

Low-level laser therapy improves repair following complete resection of the sciatic nerve in rats

Author Medalha, Carla Christina Autor UNIFESP Google Scholar
Di Gangi, Giuliana Castro Autor UNIFESP Google Scholar
Barbosa, Caroline Bublitz Autor UNIFESP Google Scholar
Fernandes, Marcela Autor UNIFESP Google Scholar
Aguiar, Odair Autor UNIFESP Google Scholar
Faloppa, Flavio Autor UNIFESP Google Scholar
Leite, Vilnei Mattioli Autor UNIFESP Google Scholar
Muniz Renno, Ana Claudia Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The aim of this study is to analyze the effects of low-level laser therapy (LLLT) on the regeneration of the sciatic nerve in rats following a complete nerve resection. Male Wistar rats were divided into a control injury group, injury groups irradiated with a 660-nm laser at 10 or 50 J/cm(2), and injury groups irradiated with an 808-nm laser at 10 or 50 J/cm(2). Treatment began 24 h following nerve resection and continued for 15 days. Using the sciatic functional index (SFI), we show that the injured animals treated with 660 nm at 10 and 50 J/cm(2) had better SFI values compared with the control injury and the 808-nm groups. Animals irradiated with the 808-nm laser at 50 J/cm(2) show higher values for fiber density than do control animals. in addition, axon and fiber diameters were larger in animals irradiated with 660 nm at 50 J/cm(2) compared to the control group. These findings indicate that 660-nm LLLT is able to provide functional gait recovery and leads to increases in fiber diameter following sciatic nerve resection.
Keywords Laser therapy
Nerve regeneration
Sciatic nerve
Language English
Date 2012-05-01
Published in Lasers in Medical Science. London: Springer London Ltd, v. 27, n. 3, p. 629-635, 2012.
ISSN 0268-8921 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 629-635
Origin http://dx.doi.org/10.1007/s10103-011-1008-9
Access rights Closed access
Type Article
Web of Science ID WOS:000302485500014
URI http://repositorio.unifesp.br/handle/11600/34842

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