ACQUIRED VITELLIFORM LESION ASSOCIATED WITH LARGE DRUSEN

ACQUIRED VITELLIFORM LESION ASSOCIATED WITH LARGE DRUSEN

Author Lima, Luiz H. Autor UNIFESP Google Scholar
Laud, Ketan Google Scholar
Freund, K. Bailey Google Scholar
Yannuzzi, Lawrence A. Google Scholar
Spaide, Richard F. Google Scholar
Institution Macula Consultants New York
Manhattan Eye Ear & Throat Hosp
Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: the purpose of this study was to describe the association of acquired vitelliform lesion (AVL) and large drusen in patients with non-neovascular age-related macular degeneration.Methods: A retrospective review of clinical examination and multimodal imaging data of patients with AVL and large drusen seen over a 12-month period was performed. Acquired vitelliform lesion was defined as subretinal accretion of hyperautofluorescent yellowish material within the macular region not due to vitelliform macular dystrophy. Large drusen were diagnosed by the presence of mounded deposits in the subretinal pigment epithelial space between the retinal pigment epithelium and the Bruch membrane using multimodal imaging analysis (color photography, autofluorescence, and spectral domain optical coherence tomography).Results: Thirteen eyes of 9 white patients with a mean age of 74 years were observed to have AVL associated with large drusen. the median visual acuity was 20/60. All AVLs were hyperautofluorescent and were located in the subretinal space between the retinal pigment epithelium and the photoreceptor inner segment/outer segment junction. the AVL in this series had similar color, autofluorescence, and optical coherence tomographic findings as the AVL seen in association with cuticular drusen and subretinal drusenoid deposits.Conclusion: Acquired vitelliform lesions, which have previously been related to cuticular drusen and subretinal drusenoid deposits, can occur in association with large drusen. Abnormalities leading to drusen formation or processes that function in parallel to these may be causative in AVL formation. RETINA 32:647-651, 2012
Keywords acquired vitelliform lesion
age-related macular degeneration
cuticular drusen
fundus autofluorescence
large drusen
spectral domain optical coherence tomography
Language English
Sponsor LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital
Macula Foundation, Inc.
Topcon Inc.
Date 2012-04-01
Published in Retina-the Journal of Retinal and Vitreous Diseases. Philadelphia: Lippincott Williams & Wilkins, v. 32, n. 4, p. 647-651, 2012.
ISSN 0275-004X (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 647-651
Origin http://dx.doi.org/10.1097/IAE.0b013e31823fb847
Access rights Closed access
Type Article
Web of Science ID WOS:000302232800001
URI http://repositorio.unifesp.br/handle/11600/34769

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