Results of a randomized controlled trial to assess the effects of a mobile SMS-based intervention on treatment adherence in HIV/AIDS-infected Brazilian women and impressions and satisfaction with respect to incoming messages

Results of a randomized controlled trial to assess the effects of a mobile SMS-based intervention on treatment adherence in HIV/AIDS-infected Brazilian women and impressions and satisfaction with respect to incoming messages

Author Costa, Thiago Martini da Autor UNIFESP Google Scholar
Peres Barbosa, Barbara Jaqueline Autor UNIFESP Google Scholar
Gomes e Costa, Durval Alex Autor UNIFESP Google Scholar
Sigulem, Daniel Google Scholar
Marin, Heimar de Fatima Google Scholar
Castelo Filho, Adauto Autor UNIFESP Google Scholar
Pisa, Ivan Torres Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To assess whether a warning system based on mobile SMS messages increases the adherence of HIV-infected Brazilian women to antiretroviral drug-based treatment regimens and their impressions and satisfaction with respect to incoming messages.Design: A randomized controlled trial was conducted from May 2009 to April 2010 with HIV-infected Brazilian women. All participants (n = 21) had a monthly multidisciplinary attendance; each participant was followed over a 4-month period, when adherence measures were obtained. Participants in the intervention group (n = 8) received SMS messages 30 min before their last scheduled time for a dose of medicine during the day. the messages were sent every Saturday and Sunday and on alternate days during the working week. Participants in the control group (n = 13) did not receive messages.Measurements: Self-reported adherence, pill counting, microelectronic monitors (MEMS) and an interview about the impressions and satisfaction with respect to incoming messages.Results: the HIV Alert System (HIVAS) was developed over 7 months during 2008 and 2009. After the study period, self-reported adherence indicated that 11 participants (84.62%) remained compliant in the control group (adherence exceeding 95%), whereas all 8 participants in the intervention group (100.00%) remained compliant. in contrast, the counting pills method indicated that the number of compliant participants was 5 (38.46%) for the control group and 4 (50.00%) for the intervention group. Microelectronic monitoring indicated that 6 participants in the control group (46.15%) were adherent during the entire 4-month period compared to 6 participants in the intervention group (75.00%). According to the feedback of the 8 participants who completed the research in the intervention group, along with the feedback of 3 patients who received SMS for less than 4 months, that is, did not complete the study, 9 (81.81%) believed that the SMS messages aided them in treatment adherence, and 10 (90.90%) responded that they would like to continue receiving SMS messages. SMS messaging can help Brazilian women living with HIV/AIDS to adhere to antiretroviral therapy for a period of at least 4 months. in general, the results are encouraging because the SMS messages stimulated more participants in the intervention group to be adherent to their treatment, and the patients were satisfied with the messages received, which were seen as reminders, incentives and signs of affection by the health clinic for a marginalized population. (c) 2012 Published by Elsevier Ireland Ltd.
Keywords Adherence
Compliance
HIV
AIDS
Reminding
Cell phones
Wireless text messaging
SMS
Language English
Sponsor NIH
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number NIH: D43TW007015-06 BRIGHT
CAPES: 0810497
CNPq: 301735/2009-3
Date 2012-04-01
Published in International Journal of Medical Informatics. Clare: Elsevier B.V., v. 81, n. 4, p. 257-269, 2012.
ISSN 1386-5056 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 257-269
Origin http://dx.doi.org/10.1016/j.ijmedinf.2011.10.002
Access rights Closed access
Type Article
Web of Science ID WOS:000301378400004
URI http://repositorio.unifesp.br/handle/11600/34760

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