Metformin versus lifestyle changes in treating women with polycystic ovary syndrome

Metformin versus lifestyle changes in treating women with polycystic ovary syndrome

Author Curi, Daniella D. G. Google Scholar
Fonseca, Angela Maggio Google Scholar
Marcondes, Jose Antonio M. Google Scholar
Almeida, Jose Alcione M. Google Scholar
Bagnoli, Vicente R. Google Scholar
Soares-, Jose Maria Autor UNIFESP Google Scholar
Baracat, Edmund Chada Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Objective: To compare the efficacy of metformin with that of lifestyle changes in patients with polycystic ovary syndrome (PCOS). Design: Prospective, randomized clinical trial of 40 women with PCOS to analyze the effects of metformin and lifestyle intervention treatments on menstrual pattern and hormone and metabolic profile. the duration of treatment was 6 months. Statistical analysis was done using Student's t-test. Results: Fifteen women in the metformin group and 12 in the lifestyle changes group completed the study. the menstrual pattern improved by similar to 67% in both groups. There was a significant decrease in waist circumference in the lifestyle changes group (101.8 +/- 3.9 and 95.1 +/- 3.6, at baseline and at 6 months of treatment, respectively; p<0.001) and in body mass index (BMI) in both groups. the predictor of menstrual pattern improvement was BMI. Conclusions: Both metformin and lifestyle changes may increase the number of menstrual cycles in PCOS. This effect was related to a decrease in BMI.
Keywords BMI
menstrual cycle
polycystic ovary syndrome
Language English
Date 2012-03-01
Published in Gynecological Endocrinology. New York: Informa Healthcare, v. 28, n. 3, p. 182-185, 2012.
ISSN 0951-3590 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 182-185
Access rights Closed access
Type Article
Web of Science ID WOS:000300436700006

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