Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy

Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy

Author Almeida, S. S. Autor UNIFESP Google Scholar
Naffah-Mazzacoratti, Maria da Graca Autor UNIFESP Google Scholar
Guimarães, Paola Bianchi Autor UNIFESP Google Scholar
Wasinski, F. Autor UNIFESP Google Scholar
Pereira, F. E. G. Autor UNIFESP Google Scholar
Canzian, Mauro Autor UNIFESP Google Scholar
Centeno, Ricardo Silva Autor UNIFESP Google Scholar
Carrete Junior, Henrique Autor UNIFESP Google Scholar
Yacubian, Elza Márcia Targas Autor UNIFESP Google Scholar
Carmona, Adriana Karaoglanovic Autor UNIFESP Google Scholar
Vieira, Renata de Freitas Fisher Autor UNIFESP Google Scholar
Nakaie, Clovis Ryuichi Autor UNIFESP Google Scholar
Sabatini, R. A. Autor UNIFESP Google Scholar
Perosa, S. R. Autor UNIFESP Google Scholar
Bacurau, Reury Frank Pereira Google Scholar
Gouveia, Telma Luciana Furtado Autor UNIFESP Google Scholar
Gallo, Gloria Autor UNIFESP Google Scholar
Wuertele, M. Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Silva, J. A. Google Scholar
Pesquero, João Bosco Autor UNIFESP Google Scholar
Araujo, R. C. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Nove de Julho Univ UNINOVE
Abstract We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems. Translational Psychiatry (2012) 2, e93; doi:10.1038/tp.2012.21; published online 13 March 2012
Keywords angiotensin I-converting enzyme
carbamazepine
epilepsy
TLE
Language English
Sponsor INNT
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2012-03-01
Published in Translational Psychiatry. New York: Nature Publishing Group, v. 2, 5 p., 2012.
ISSN 2158-3188 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent 5
Origin http://dx.doi.org/10.1038/tp.2012.21
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000315990800009
URI http://repositorio.unifesp.br/handle/11600/34639

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