Contributions of Neuroimaging to Understanding Sex Differences in Cocaine Abuse

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dc.contributor.author Andersen, Monica L. [UNIFESP]
dc.contributor.author Sawyer, Eileen K.
dc.contributor.author Howell, Leonard L.
dc.date.accessioned 2016-01-24T14:17:53Z
dc.date.available 2016-01-24T14:17:53Z
dc.date.issued 2012-02-01
dc.identifier http://dx.doi.org/10.1037/a0025219
dc.identifier.citation Experimental and Clinical Psychopharmacology. Washington: Amer Psychological Assoc, v. 20, n. 1, p. 2-15, 2012.
dc.identifier.issn 1064-1297
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34600
dc.description.abstract A consistent observation in drug abuse research is that males and females show differences in their response to drugs of abuse. in order to understand the neurobiology underlying cocaine abuse and effective treatments, it is important to consider the role of sex differences. Sex hormones have been investigated in both behavioral and molecular studies, but further evidence addressing drug abuse and dependence in both sexes would expand our knowledge of sex differences in response to drugs of abuse. Neuroimaging is a powerful tool that can offer insight into the biological bases of these differences and meet the challenges of directly examining drug-induced changes in brain function. As such, neuroimaging has drawn much interest in recent years. Specifically, positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) technology have emerged as effective noninvasive approaches for human and animal models. Studies have revealed sex-specific changes in patterns of brain activity in response to acute cocaine injection and after prolonged cocaine use. SPECT and PET studies have demonstrated changes in the dopamine transporter but are less clear on other components of the dopaminergic system. This review highlights contributions of neuroimaging toward understanding the role of sex differences in the drug abuse field, specifically regarding cocaine, and identifies relevant questions that neuroimaging can effectively address. en
dc.description.sponsorship USPHS
dc.description.sponsorship Associacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 2-15
dc.language.iso eng
dc.publisher Amer Psychological Assoc
dc.relation.ispartof Experimental and Clinical Psychopharmacology
dc.rights Acesso restrito
dc.subject drug abuse en
dc.subject neuroimaging en
dc.subject sex differences en
dc.subject cocaine en
dc.subject MRI en
dc.subject PET en
dc.subject SPECT en
dc.title Contributions of Neuroimaging to Understanding Sex Differences in Cocaine Abuse en
dc.type Artigo
dc.contributor.institution Emory Univ
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA
dc.description.affiliation Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliation Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30329 USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.sponsorshipID USPHS: DA10344
dc.description.sponsorshipID USPHS: DA12514
dc.description.sponsorshipID USPHS: DA00517
dc.description.sponsorshipID USPHS: T32-DA015040
dc.description.sponsorshipID USPHS: RR00165
dc.identifier.doi 10.1037/a0025219
dc.description.source Web of Science
dc.identifier.wos WOS:000299864200002



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