Contributions of Neuroimaging to Understanding Sex Differences in Cocaine Abuse

Contributions of Neuroimaging to Understanding Sex Differences in Cocaine Abuse

Author Andersen, Monica L. Autor UNIFESP Google Scholar
Sawyer, Eileen K. Google Scholar
Howell, Leonard L. Google Scholar
Institution Emory Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract A consistent observation in drug abuse research is that males and females show differences in their response to drugs of abuse. in order to understand the neurobiology underlying cocaine abuse and effective treatments, it is important to consider the role of sex differences. Sex hormones have been investigated in both behavioral and molecular studies, but further evidence addressing drug abuse and dependence in both sexes would expand our knowledge of sex differences in response to drugs of abuse. Neuroimaging is a powerful tool that can offer insight into the biological bases of these differences and meet the challenges of directly examining drug-induced changes in brain function. As such, neuroimaging has drawn much interest in recent years. Specifically, positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) technology have emerged as effective noninvasive approaches for human and animal models. Studies have revealed sex-specific changes in patterns of brain activity in response to acute cocaine injection and after prolonged cocaine use. SPECT and PET studies have demonstrated changes in the dopamine transporter but are less clear on other components of the dopaminergic system. This review highlights contributions of neuroimaging toward understanding the role of sex differences in the drug abuse field, specifically regarding cocaine, and identifies relevant questions that neuroimaging can effectively address.
Keywords drug abuse
sex differences
Language English
Sponsor USPHS
Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number USPHS: DA10344
USPHS: DA12514
USPHS: DA00517
USPHS: T32-DA015040
USPHS: RR00165
Date 2012-02-01
Published in Experimental and Clinical Psychopharmacology. Washington: Amer Psychological Assoc, v. 20, n. 1, p. 2-15, 2012.
ISSN 1064-1297 (Sherpa/Romeo, impact factor)
Publisher Amer Psychological Assoc
Extent 2-15
Access rights Closed access
Type Article
Web of Science ID WOS:000299864200002

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