Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)

Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)

Author Torres de Oliveira, Antonio Talvane Google Scholar
Pinheiro, Celine Google Scholar
Longatto-Filho, Adhemar Google Scholar
Brito, Maria Jose Google Scholar
Martinho, Olga Google Scholar
Matos, Delcio Autor UNIFESP Google Scholar
Carvalho, Andre Lopes Google Scholar
Vazquez, Vinicius Lima Google Scholar
Silva, Thiago Buosi Google Scholar
Scapulatempo, Cristovam Google Scholar
Saad, Sarhan Sydney Autor UNIFESP Google Scholar
Reis, Rui Manuel Google Scholar
Baltazar, Fatima Google Scholar
Institution Univ Minho
Barretos Canc Hosp
ICVS 3Bs PT Govt Associate Lab
Universidade de São Paulo (USP)
Hosp Garcia Orta
Universidade Federal de São Paulo (UNIFESP)
Abstract Monocarboxylate transporters (MCTs) have been described to play an important role in cancer, but to date there are no reports on the significance of MCT expression in gastrointestinal stromal tumors (GISTs). the aim of the present work was to assess the value of MCT expression, as well as co-expression with the MCT chaperone CD147 in GISTs and evaluate their clinical-pathological significance. We analyzed the immunohistochemical expression of MCT1, MCT2, MCT4 and CD147 in a series of 64 GISTs molecularly characterized for KIT, PDGFRA and BRAF mutations. MCT1, MCT2 and MCT4 were highly expressed in GISTs. CD147 expression was associated with mutated KIT (p = 0.039), as well as a progressive increase in Fletcher's Risk of Malignancy (p = 0.020). Importantly, co-expression of MCT1 with CD147 was associated with low patient's overall survival (p = 0.037). These findings suggest that co-expression of MCT1 with its chaperone CD147 is involved in GISTs aggressiveness, pointing to a contribution of cancer cell metabolic adaptations in GIST development and/or progression.
Keywords Monocarboxylate transporters
CD147
Cancer metabolism
GISTs
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Portuguese Science and Technology Foundation
Grant number CNPq: 476936/2008-0
Portuguese Science and Technology Foundation: SFRH/BPD/69479/2010
Portuguese Science and Technology Foundation: SFRH/BD/36463/2007
Date 2012-02-01
Published in Journal of Bioenergetics and Biomembranes. New York: Springer/plenum Publishers, v. 44, n. 1, p. 171-178, 2012.
ISSN 0145-479X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 171-178
Origin http://dx.doi.org/10.1007/s10863-012-9408-5
Access rights Closed access
Type Article
Web of Science ID WOS:000301843000016
URI http://repositorio.unifesp.br/handle/11600/34568

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