Morbimortality of Pandemic Influenza A H1N1 Infection in Kidney Transplant Recipients Requiring Hospitalization: A Comparative Analysis With Nonimmunocompromised Patients

Morbimortality of Pandemic Influenza A H1N1 Infection in Kidney Transplant Recipients Requiring Hospitalization: A Comparative Analysis With Nonimmunocompromised Patients

Author Camargo, Luis Fernando A. Autor UNIFESP Google Scholar
Sandes-Freitas, Taina V. de Autor UNIFESP Google Scholar
Silva, Camila D. R. Autor UNIFESP Google Scholar
Bittante, Carolina D. Autor UNIFESP Google Scholar
Ono, Gislaine Autor UNIFESP Google Scholar
Correa, Luci Autor UNIFESP Google Scholar
Silva, Moacyr Autor UNIFESP Google Scholar
Bellei, Nancy Cristina J. Autor UNIFESP Google Scholar
Goto, Janaina M. Autor UNIFESP Google Scholar
Medeiros, Eduardo A. S. Autor UNIFESP Google Scholar
Gomes, Pollyane S. Autor UNIFESP Google Scholar
Medina-Pestana, Jose O. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Rim & Hipertensao
Abstract Background. Clinical and epidemiological data of pandemic influenza A H1N1 infection in solid-organ transplant recipients have been described, but scarce data compare these outcomes with nonimmunocompromised patients.Methods. We retrospectively reviewed and compared the clinical presentation, morbidity, and mortality of all kidney transplant (KT) and nonimmunocompromised (non-KT) patients admitted for at least 12 hr with a diagnosis of pandemic influenza A H1N1 infection in a single hospital complex during the 2009 pandemic.Results. There were 22 patients in the KT group (29.3%) and 53 in the non-KT group (70.7%). the prevalence of diabetes was higher in KT group (27.3% vs. 5.7%) while chronic pulmonary disease was more frequent in non-KT group (34% vs. 9.1%). Clinical and radiological presentations and duration of disease were similar between the two groups. the incidence of acute renal failure was higher among KT patients (40.9% vs. 17%). No differences in the rate of intensive care unit admission (22.7% vs. 22.6%) or hospital mortality (9.1% vs. 7.5%) were observed. for the overall population, poor outcome, defined as intensive care unit admission or death, was associated with in-hospital acquisition (relative risk [RR] = 42.6 [95% confidence interval {95% CI} 2.2-831.9], P = 0.003), symptom onset more than 48 hr (RR = 12.17 [95% CI 1.3-117.2], P = 0.007), and acute renal failure (RR = 11.8 [95% CI 2.9-48.8], P = 0.001). Among KT recipients, in-hospital acquisition was the only covariate associate with poor outcome (RR = 30.0 [95% CI 2.1421.1], P = 0.004).Conclusions. No significant differences in morbidity and mortality were observed comparing KT and non-KT patients infected with pandemic H1N1 influenza A virus.
Keywords H1N1
Influenza
Transplantation
Language English
Date 2012-01-15
Published in Transplantation. Philadelphia: Lippincott Williams & Wilkins, v. 93, n. 1, p. 69-72, 2012.
ISSN 0041-1337 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 69-72
Origin http://dx.doi.org/10.1097/TP.0b013e31823aa528
Access rights Closed access
Type Article
Web of Science ID WOS:000298660800011
URI http://repositorio.unifesp.br/handle/11600/34530

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