Cocaine administration increases angiotensin I-converting enzyme (ACE) expression and activity in the rat striatum and frontal cortex

Cocaine administration increases angiotensin I-converting enzyme (ACE) expression and activity in the rat striatum and frontal cortex

Author Visniauskas, Bruna Autor UNIFESP Google Scholar
Perry, Juliana Cini Autor UNIFESP Google Scholar
Oliveira, Vitor Autor UNIFESP Google Scholar
Dalio, Fernanda Montiel Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Chagas, Jair Ribeiro Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Some central effects of cocaine administration seem to be related to angiotensin II (Ang II) or its metabolites. Nonetheless, it is still an open question whether or not the levels of angiotensin I-converting enzyme (ACE), the main Ang II generating enzyme, are modified by cocaine administration. To evaluate the effect of acute and subchronic cocaine administration on ACE activity and mRNA expression, male rats were randomly assigned to saline or cocaine group. Acute and subchronic cocaine administration induced a significant increase in ACE activity and mRNA expression in the frontal cortex and striatum but not in the hippocampus. These results suggest that some of the Ang II related effects of cocaine upon the central nervous system can be mediated by changes on the expression and activity of ACE in the striatum and frontal cortex. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved.
Keywords Angiotensin I-converting enzyme (ACE)
Angiotensin II (Ang II)
Central nervous system
Cocaine
Frontal cortex
Striatum
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 98/14303-3
CNPq: 558924/2008-5
CNPq: 481104/2004-6
Date 2012-01-06
Published in Neuroscience Letters. Clare: Elsevier B.V., v. 506, n. 1, p. 84-88, 2012.
ISSN 0304-3940 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 84-88
Origin http://dx.doi.org/10.1016/j.neulet.2011.10.054
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000300205000017
URI http://repositorio.unifesp.br/handle/11600/34526

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