5-HT2A receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated T-maze

5-HT2A receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated T-maze

Author Paula, D. C. de Autor UNIFESP Google Scholar
Torricelli, A. S. Autor UNIFESP Google Scholar
Lopreato, M. R. Autor UNIFESP Google Scholar
Nascimento, J. O. G. Autor UNIFESP Google Scholar
Viana, M. B. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Serotonin in the lateral septum has been implicated in the modulation of defense and hence in anxiety. However, it deserves investigation how changes in 5-HT-mechanisms in this area modulate defensive responses associated with specific subtypes of anxiety disorders. We evaluated the effects of intra-dorsolateral septum (DLS) injections of the preferential 5-HT2A receptor agonist DOI (8 and 16 nmol), the 5-HT2C selective agonist MK-212 (0.1 and 1 nmol) and the preferential 5-HT2A antagonist ketanserin (10 and 20 nmol) in rats exposed to the elevated T-maze (ETM), a model which allows the measurement of two defensive responses: inhibitory avoidance and escape. These responses have been respectively related to generalized anxiety and panic disorder. All animals were tested in an open-field after the ETM for locomotor activity assessments. Results showed that intra-DLS DOI increased avoidance latencies, an anxiogenic effect. MK and ketanserin were without effect. Also, none of the drugs administered affected the escape performance. Ketanserin blocked the anxiogenic effect caused by DOL. No changes to locomotion were observed. the data suggests that DLS 5-HT2A receptors are involved in the control of inhibitory avoidance and that a failure in this mechanism may be of importance to the physiopathology of generalized anxiety. (C) 2011 Elsevier B.V. All rights reserved.
Keywords Dorsolateral septum
5-HT2A/2C receptors
Anxiety
Panic
Elevated T-maze
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 08/58815-1
Date 2012-01-01
Published in Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 226, n. 1, p. 50-55, 2012.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 50-55
Origin http://dx.doi.org/10.1016/j.bbr.2011.08.044
Access rights Closed access
Type Article
Web of Science ID WOS:000296941400007
URI http://repositorio.unifesp.br/handle/11600/34447

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