Differences between dextroamphetamine and methamphetamine: behavioral changes and oxidative damage in brain of Wistar rats

Differences between dextroamphetamine and methamphetamine: behavioral changes and oxidative damage in brain of Wistar rats

Author da-Rosa, Dayane D. Google Scholar
Valvassori, Samira S. Google Scholar
Steckert, Amanda V. Google Scholar
Arent, Camila O. Google Scholar
Ferreira, Camila L. Google Scholar
Lopes-Borges, Jessica Google Scholar
Varela, Roger B. Google Scholar
Mariot, Edemilson Google Scholar
Dal-Pizzol, Felipe Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Quevedo, Joao Google Scholar
Institution Univ Extremo Catarinense
Univ So Santa Catarina
Universidade Federal de São Paulo (UNIFESP)
Abstract In this study methamphetamine (m-AMPH) and dextroamphetamine (d-AMPH) were compared to determine the potency of the two drugs on behavior and oxidative damage in brain of rats. Male adult Wistar rats were given single (acute administration) or repeated (chronic administration, 14 days) intraperitoneal injections of saline (0.9% NaCl), d-AMPH (2 mg/kg) or m-AMPH (0.25, 0.5, 1 or 2 mg/kg). Locomotor activity was evaluated in open-field apparatus 2 h after the last drug injection. Additionally, thiobarbituric acid reactive substances (TBARS) and protein carbonyl formation were measured in the prefrontal cortex, amygdala, hippocampus and striatum. in both experiments, d-AMPH and m-AMPH (all doses administered) increased the locomotor activity of animals, meantime, no significant difference between d-AMPH and m-AMPH was observed. d-AMPH and m-AMPH increased lipid and protein damage, but m-AMPH was more potent than d-AMPH, however, this effect varies depending on the brain region and the experimental protocol. the results of this study show that d-AMPH and m-AMPH have similar behavioral effects, which previous studies had already reported. On the other hand, this study demonstrated that the m-AMPH induces oxidative damage greater than d-AMPH, showing neurochemical differences previously unknown.
Keywords Dextroamphetamine
Oxidative damage
Locomotor activity
Exploratory activity
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2012-01-01
Published in Journal of Neural Transmission. Wien: Springer Wien, v. 119, n. 1, p. 31-38, 2012.
ISSN 0300-9564 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 31-38
Origin http://dx.doi.org/10.1007/s00702-011-0691-9
Access rights Closed access
Type Article
Web of Science ID WOS:000298883600006
URI http://repositorio.unifesp.br/handle/11600/34439

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