Interdisciplinary therapy improves biomarkers profile and lung function in asthmatic obese adolescents

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dc.contributor.author Silva, Patricia Leao da [UNIFESP]
dc.contributor.author Mello, Marco Tulio de [UNIFESP]
dc.contributor.author Cheik, Nadia Carla
dc.contributor.author Sanches, Priscila Lima [UNIFESP]
dc.contributor.author Correia, Fabiola Alvise [UNIFESP]
dc.contributor.author Piano, Aline de [UNIFESP]
dc.contributor.author Corgosinho, Flavia Campos [UNIFESP]
dc.contributor.author Silveira Campos, Raquel Munhoz da [UNIFESP]
dc.contributor.author Nascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.author Oyama, Lila Missae [UNIFESP]
dc.contributor.author Tock, Lian [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Dâmaso, Ana Raimunda [UNIFESP]
dc.date.accessioned 2016-01-24T14:17:41Z
dc.date.available 2016-01-24T14:17:41Z
dc.date.issued 2012-01-01
dc.identifier https://onlinelibrary.wiley.com/doi/full/10.1002/ppul.21502
dc.identifier.citation Pediatric Pulmonology. Hoboken: Wiley-Blackwell, v. 47, n. 1, p. 8-17, 2012.
dc.identifier.issn 8755-6863
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/34434
dc.description.abstract Background the simultaneous rise in the prevalence of asthma and obesity in the world, have demonstrated the importance of the development of treatment strategies. the purpose of this study was to evaluate the short- and long-term results of interdisciplinary therapy on inflammatory biomarkers and lung function in asthmatics obese adolescents. Methods: Seventy- six post-pubertal obese adolescents were recruited, including 50 non-asthmatics [body mass index (BMI), 36 +/- 5 kg/m(2)) and 26 asthmatics (BMI, 39 +/- 4 kg/m(2)). Body composition was measured by plethysmography, and visceral fat was analyzed by ultrasound. Serum levels of adiponectin, leptin, and C-reactive protein (CRP) were analyzed. Asthma and lung function were evaluated according to the American Thoracic Society criteria. Patients were submitted to 1-year weight loss interdisciplinary intervention consisting of medical, nutritional, exercise, and psychological therapy. Results: After interdisciplinary intervention, the lung function and pro/anti-inflammatory adipokines improved significantly in both groups. Most importantly, there was an increase in adiponectin [4 (1.86-12.9) to 5.1 (2.48-16)], a reduction in CRP [2,073 (385-9,174) to 1,538 (205-7,083)] and leptin concentrations [59 (29-69) to 33 (9-49)] in the asthmatics patients. Furthermore, it was observed a reduction in asthma severity after treatment. in addition, Delta adiponectin was an independent factor to improve lung function after therapy in both groups. Conclusions: Interdisciplinary therapy resulted in beneficial changes in inflammatory biomarkers profile and lung function in asthmatic and non-asthmatic obese adolescents. Additionally, for the first time we showed that change in adiponectin level was an independent predictor to improve lung function in Brazilian obese adolescents. Pediatr Pulmonol. 2012; 47: 8-17. (C) 2011 Wiley Periodicals, Inc. en
dc.description.sponsorship AFIP
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship CENESP
dc.description.sponsorship FADA
dc.description.sponsorship UNIFESP
dc.format.extent 8-17
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Pediatric Pulmonology
dc.rights Acesso restrito
dc.subject Obesity en
dc.subject Asthma en
dc.subject Adipokine en
dc.subject Adolescence en
dc.subject Therapy en
dc.title Interdisciplinary therapy improves biomarkers profile and lung function in asthmatic obese adolescents en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Federal de Uberlândia (UFU)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliation Univ Fed Uberlandia, BR-38400 Uberlandia, MG, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Post Grad Program Interdisciplinary Hlth Sci, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Post Grad Program Nutr, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Post Grad Program Interdisciplinary Hlth Sci, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Post Grad Program Nutr, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2008/53069-0
dc.description.sponsorshipID FAPESP: 2006/00684-3
dc.description.sponsorshipID FAPESP: 98/14303-3
dc.identifier.doi 10.1002/ppul.21502
dc.description.source Web of Science
dc.identifier.wos WOS:000298590800002



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