Interdisciplinary therapy improves biomarkers profile and lung function in asthmatic obese adolescents

Interdisciplinary therapy improves biomarkers profile and lung function in asthmatic obese adolescents

Author Silva, Patricia Leao da Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Cheik, Nadia Carla Google Scholar
Sanches, Priscila Lima Autor UNIFESP Google Scholar
Correia, Fabiola Alvise Autor UNIFESP Google Scholar
Piano, Aline de Autor UNIFESP Google Scholar
Corgosinho, Flavia Campos Autor UNIFESP Google Scholar
Silveira Campos, Raquel Munhoz da Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Tock, Lian Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Uberlândia (UFU)
Abstract Background the simultaneous rise in the prevalence of asthma and obesity in the world, have demonstrated the importance of the development of treatment strategies. the purpose of this study was to evaluate the short- and long-term results of interdisciplinary therapy on inflammatory biomarkers and lung function in asthmatics obese adolescents. Methods: Seventy- six post-pubertal obese adolescents were recruited, including 50 non-asthmatics [body mass index (BMI), 36 +/- 5 kg/m(2)) and 26 asthmatics (BMI, 39 +/- 4 kg/m(2)). Body composition was measured by plethysmography, and visceral fat was analyzed by ultrasound. Serum levels of adiponectin, leptin, and C-reactive protein (CRP) were analyzed. Asthma and lung function were evaluated according to the American Thoracic Society criteria. Patients were submitted to 1-year weight loss interdisciplinary intervention consisting of medical, nutritional, exercise, and psychological therapy. Results: After interdisciplinary intervention, the lung function and pro/anti-inflammatory adipokines improved significantly in both groups. Most importantly, there was an increase in adiponectin [4 (1.86-12.9) to 5.1 (2.48-16)], a reduction in CRP [2,073 (385-9,174) to 1,538 (205-7,083)] and leptin concentrations [59 (29-69) to 33 (9-49)] in the asthmatics patients. Furthermore, it was observed a reduction in asthma severity after treatment. in addition, Delta adiponectin was an independent factor to improve lung function after therapy in both groups. Conclusions: Interdisciplinary therapy resulted in beneficial changes in inflammatory biomarkers profile and lung function in asthmatic and non-asthmatic obese adolescents. Additionally, for the first time we showed that change in adiponectin level was an independent predictor to improve lung function in Brazilian obese adolescents. Pediatr Pulmonol. 2012; 47: 8-17. (C) 2011 Wiley Periodicals, Inc.
Keywords Obesity
Asthma
Adipokine
Adolescence
Therapy
Language English
Sponsor AFIP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
CENESP
FADA
UNIFESP
Grant number FAPESP: 2008/53069-0
FAPESP: 2006/00684-3
FAPESP: 98/14303-3
Date 2012-01-01
Published in Pediatric Pulmonology. Hoboken: Wiley-Blackwell, v. 47, n. 1, p. 8-17, 2012.
ISSN 8755-6863 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 8-17
Origin https://onlinelibrary.wiley.com/doi/full/10.1002/ppul.21502
Access rights Closed access
Type Article
Web of Science ID WOS:000298590800002
URI https://repositorio.unifesp.br/handle/11600/34434

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