Pediatric Central Nervous System Tumors: A Single-center Experience From 1989 to 2009

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dc.contributor.author Pinho, Ricardo Silva [UNIFESP]
dc.contributor.author Andreoni, Solange [UNIFESP]
dc.contributor.author Silva, Nasjla Saba [UNIFESP]
dc.contributor.author Cappellano, Andrea Maria [UNIFESP]
dc.contributor.author Masruha, Marcelo Rodrigues [UNIFESP]
dc.contributor.author Cavalheiro, Sergio [UNIFESP]
dc.contributor.author Pereira Vilanova, Luiz Celso [UNIFESP]
dc.date.accessioned 2016-01-24T14:17:33Z
dc.date.available 2016-01-24T14:17:33Z
dc.date.issued 2011-12-01
dc.identifier http://dx.doi.org/10.1097/MPH.0b013e31822031d9
dc.identifier.citation Journal of Pediatric Hematology Oncology. Philadelphia: Lippincott Williams & Wilkins, v. 33, n. 8, p. 605-609, 2011.
dc.identifier.issn 1077-4114
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34312
dc.description.abstract The objective of this study was to determine the epidemiology of primary tumors of the central nervous system (CNS) in pediatric patients from a Brazilian oncology institute. We retrospectively analyzed 741 charts (415 males and 326 females) of patients under 21 years of age who were diagnosed with a CNS tumor. the analysis included patients from 1989 to 2009 and was performed using the World Health Organization criteria. We evaluated the distribution of age, sex, topography, clinical symptoms, symptom intervals, and classification of the tumors. Patients with clinical/radiologic diagnoses were included. Seven hundred forty-one patients with tumors in the CNS were reviewed, and 83% of the patients presented a histologic diagnosis. Males (56%) were more prevalent than females. in children under the age of 1 year, the supratentorial compartment was the predominant region involved (62.0%). Astrocytoma was the most frequent tumor type (37.0%), followed by medulloblastoma (13.6%), craniopharyngioma (10.5%), and ependymoma (6.8%). Headaches were the most common symptom, and the symptom intervals varied from 1 to 5010 days. Approximately 4% of the patients had associated genetic syndromes. Although it was not a population study and selection bias may have occurred, this study supplies important epidemiologic data from an emerging country in which population studies are rare. en
dc.format.extent 605-609
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Journal of Pediatric Hematology Oncology
dc.rights Acesso restrito
dc.subject central nervous system en
dc.subject neoplasms en
dc.subject child en
dc.subject epidemiology en
dc.title Pediatric Central Nervous System Tumors: A Single-center Experience From 1989 to 2009 en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Prevent Med, BR-04023900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pediat, Pediat Oncol Inst, BR-04023900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Support Grp Children & Adolescents Canc, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Prevent Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pediat, Pediat Oncol Inst, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Support Grp Children & Adolescents Canc, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1097/MPH.0b013e31822031d9
dc.description.source Web of Science
dc.identifier.wos WOS:000296720800018



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