Genomic instability in blood cells from murine model of mucopolysaccharidosis type I

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dc.contributor.author Noguti, Juliana [UNIFESP]
dc.contributor.author Pereira, Vanessa Goncalves [UNIFESP]
dc.contributor.author Martins, Ana Maria [UNIFESP]
dc.contributor.author D'Almeida, Vania [UNIFESP]
dc.contributor.author Ribeiro, Daniel Araki [UNIFESP]
dc.date.accessioned 2016-01-24T14:17:30Z
dc.date.available 2016-01-24T14:17:30Z
dc.date.issued 2011-12-01
dc.identifier http://dx.doi.org/10.1007/s10735-011-9361-3
dc.identifier.citation Journal of Molecular Histology. Dordrecht: Springer, v. 42, n. 6, p. 575-578, 2011.
dc.identifier.issn 1567-2379
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34277
dc.description.abstract Mucopolysaccharidosis type I (MPS I) is caused by a deficiency of alfa-iduronidase (IDUA), which leads to intralysosomal accumulation of glycosaminoglycans. Some studies have revealed that oxidative stress plays an important role in MPS I. However, the mechanisms by which these alterations occur are still not fully understood. the aim of this study was to analyze genomic instability in blood cells from murine model of MPS I by single cell gel (comet) assay and micronucleus test. the results pointed out genetic damage in blood cells as depicted by the single cell gel (comet) assay results. By contrast, no increase of micronucleated cells were found in mouse blood cells when compared to negative control. Taken together, our results suggest that IDUA deficiency induces genomic damage in blood cells. Certainly, this finding offers new insights into the mechanisms underlying the relation between IDUA deficiency and clinical manifestations that can occur in MPS I patients. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship AFIP
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 575-578
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Journal of Molecular Histology
dc.rights Acesso restrito
dc.subject Mucopolysaccharidosis en
dc.subject Blood cells en
dc.subject Genomic damage en
dc.title Genomic instability in blood cells from murine model of mucopolysaccharidosis type I en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Biociencias, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Patol, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pediat, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Psicobiol, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biociencias, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Patol, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pediat, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psicobiol, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.sponsorshipID CNPq: 501343/2010-5
dc.identifier.doi 10.1007/s10735-011-9361-3
dc.description.source Web of Science
dc.identifier.wos WOS:000300371400010



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