Suicidality in temporal lobe epilepsy: Measuring the weight of impulsivity and depression

Suicidality in temporal lobe epilepsy: Measuring the weight of impulsivity and depression

Author Oliveira, Guilherme Nogueira M. de Google Scholar
Kummer, Arthur Google Scholar
Salgado, Joao Vinicius Google Scholar
Araujo Filho, Gerardo Maria de Autor UNIFESP Google Scholar
David, Anthony S. Google Scholar
Teixeira, Antonio Lucio Google Scholar
Institution Hosp Felicio Rocho
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
Kings Coll London
Abstract Objective: the aim of the work described here was to measure the role of psychopathological features, specifically impulsivity and depression, in suicidality in patients with temporal lobe epilepsy (TLE).Methods: Neuropsychiatric evaluation of 66 outpatients with TLE was performed with the following instruments: a structured clinical interview (Mini International Neuropsychiatric Interview Plus), the Barratt Impulsiveness Scale, the Hamilton Anxiety Scale, the Beck Depression Inventory, and the Brief Psychiatric Rating Scale.Results: A current Axis I psychiatric diagnosis, mainly mood and anxiety disorders, was assigned to 37 subjects (56.1%) Presence of suicide risk was identified in 19 patients (28.8%), and 14(21.2%) had attempted suicide. Frequency of seizures (P = 0.012), current major depression (P = 0.001), and motor impulsivity (P = 0.005) were associated with suicide risk on univariate analysis. Logistic regression stressed the main relevance of major depression (OR = 12.82, 95% CI = 2.58-63.76, P = 0.002) and motor impulsivity (OR = 1.21, 95% CI = 1.06-1.38, P = 0.005) to suicide risk.Conclusion: Depression has a major influence on suicidality in epilepsy. Motor impulsivity is also relevant and may be an important component of depression in TLE associated with suicide risk. (C) 2011 Elsevier Inc. All rights reserved.
Keywords Epilepsy
Temporal lobe epilepsy
Antiepileptic drugs
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2011-12-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 22, n. 4, p. 745-749, 2011.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 745-749
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000298067600019

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