Effects of group exposure on single injection-induced behavioral sensitization to drugs of abuse in mice

Effects of group exposure on single injection-induced behavioral sensitization to drugs of abuse in mice

Author Procopio-Souza, Roberta Autor UNIFESP Google Scholar
Fukushiro, Daniela F. Autor UNIFESP Google Scholar
Trombin, Thais F. Autor UNIFESP Google Scholar
Wuo-Silva, Raphael Autor UNIFESP Google Scholar
Zanlorenci, Lineane H. F. Autor UNIFESP Google Scholar
Lima, Alexandre J. O. Autor UNIFESP Google Scholar
Ribeiro, Luciana T. C. Autor UNIFESP Google Scholar
Correa, Jussara M. R. M. Autor UNIFESP Google Scholar
Marinho, Eduardo A. V. Autor UNIFESP Google Scholar
Kameda, Sonia R. Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Behavioral sensitization in rodents is hypothesized to reflect neuronal adaptations that are related to drug addiction in humans. We evaluated the effects of group exposure on the acute hyperlocomotion and behavioral sensitization induced by four drugs of abuse in C57BL/6 mice: methylenedioxymethamphetamine (MDMA), d-amphetamine, morphine and ethanol.Methods: in the priming session, animals received an ip injection of one of the drugs of abuse and were exposed to an open field either individually or in groups of four. Seven days later, we assessed behavioral sensitization in the challenge session. All animals received an ip injection of the same drug and were exposed to the open field in the same social conditions described for the priming session. Locomotion and social interaction were quantified during each session.Results: Acute MDMA, morphine and ethanol, but not d-amphetamine, increased social interaction. However, group exposure only potentiated MDMA-induced hyperlocomotion. After a challenge injection of each drug, there was no sensitization to the facilitating effect of MDMA, morphine or ethanol on social interaction, but locomotion sensitization developed to all drugs of abuse except ethanol. This sensitization was potentiated by group exposure in MDMA-treated animals, attenuated in morphine-treated animals and not modified in d-amphetamine-treated animals. Acute MDMA enhanced body contact and peaceful following, while acute morphine and ethanol increased social sniffing.Conclusions: These results provide preclinical evidence showing that while different drugs of abuse affect different components of social interaction, the neuronal adaptations related to drug dependence can be critically and specifically influenced by group exposure. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Keywords Behavioral sensitization
Drugs of abuse
Group exposure
Hyperlocomotion
Social interaction
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
FADA
AFIP
Date 2011-11-01
Published in Drug and Alcohol Dependence. Clare: Elsevier B.V., v. 118, n. 2-3, p. 349-359, 2011.
ISSN 0376-8716 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 349-359
Origin http://dx.doi.org/10.1016/j.drugalcdep.2011.04.017
Access rights Closed access
Type Article
Web of Science ID WOS:000296173800037
URI http://repositorio.unifesp.br/handle/11600/34188

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