Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profile

Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profile

Author Martins, Heloise Helena Autor UNIFESP Google Scholar
Alonso, Neide Barreira Autor UNIFESP Google Scholar
Vidal-Dourado, Marcos Autor UNIFESP Google Scholar
Carbonel, Thiago Delfino Autor UNIFESP Google Scholar
Araujo Filho, Gerardo Maria de Autor UNIFESP Google Scholar
Caboclo, Luís Otávio Sales Ferreira Autor UNIFESP Google Scholar
Yacubian, Elza Márcia Targas Autor UNIFESP Google Scholar
Guilhoto, Laura Maria de Figueiredo Ferreira Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract We report the results of administration of the Portuguese-Brazilian translation of the Liverpool Adverse Events Profile (LAEP) to 100 patients (mean age = 34.5, SD = 12.12; 56 females), 61 with symptomatic partial epilepsy (SPE) and 39 with idiopathic generalized epilepsy (ICE) (ILAE, 1989) who were on a stable antiepileptic drug (AED) regimen and being treated in a Brazilian tertiary epilepsy center. Carbamazepine was the most commonly used AED (43.0%), followed by valproic acid (32.0%). Two or more AEDs were used by 69.0% of patients. the mean LAEP score (19 questions) was 37.6 (SD = 13.35). the most common adverse effects were sleepiness (35.0%), memory problems (35.0%), and difficulty in concentrating (25.0%). Higher LAEP scores were associated with polytherapy with three or more AEDs (P=0.005), female gender (P<0.001), older age (P<0.001), and uncontrolled seizures (P = 0.045). the intraclass coefficient (test-retest reliability) for LAEP overall score was 0.848 (95% CI = 0.782-0.895), with a range from 0.370 (unsteadiness) to 0.750 (memory problems). Cronbach's alpha coefficient (internal consistency) was 0.903. the LAEP was highly correlated with Quality of Life in Epilepsy-31 inventory (r = -0.804, P>0.001) and Hospital Anxiety and Depression Scale (Depression: r = 0.637, P<0.001; Anxiety: r = 0.621, P<0.001) dimensions. LAEP overall scores were similar in people with SPE and IGE and were not helpful in differentiating adverse effects in these two groups. Clinical variables that influenced global LAEP were seizure frequency (P = 0.050) and generalized tonic-clonic seizures in the last month (P = 0.031) in the ICE group, and polytherapy with three or more AEDs (P = 0.003 and P = 0.003) in both ICE and SPE groups. (C) 2011 Elsevier Inc. All rights reserved.
Keywords Liverpool Adverse Events Profile
Antiepileptic drugs
Epilepsy
Adverse effects
Symptomatic partial epilepsy
Idiopathic generalized epilepsy
Validation
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2011-11-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 22, n. 3, p. 511-517, 2011.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 511-517
Origin http://dx.doi.org/10.1016/j.yebeh.2011.08.005
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000296826700017
URI http://repositorio.unifesp.br/handle/11600/34163

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