Addictive potential of modafinil and cross-sensitization with cocaine: a pre-clinical study

Addictive potential of modafinil and cross-sensitization with cocaine: a pre-clinical study

Author Wuo-Silva, Raphael Autor UNIFESP Google Scholar
Fukushiro, Daniela F. Autor UNIFESP Google Scholar
Borcoi, Aline R. Autor UNIFESP Google Scholar
Fernandes, Helaine A. Autor UNIFESP Google Scholar
Procopio-Souza, Roberta Autor UNIFESP Google Scholar
Hollais, Andre W. Autor UNIFESP Google Scholar
Santos, Renan Autor UNIFESP Google Scholar
Ribeiro, Luciana T. C. Autor UNIFESP Google Scholar
Correa, Jussara M. R. M. Autor UNIFESP Google Scholar
Talhati, Fernanda Autor UNIFESP Google Scholar
Saito, Luis P. Autor UNIFESP Google Scholar
Aramini, Tatiana C. F. Autor UNIFESP Google Scholar
Kameda, Sonia R. Autor UNIFESP Google Scholar
Bittencourt, Lia R. A. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Repeated or even a single exposure to drugs of abuse can lead to persistent locomotor sensitization, which is the result of an abundance of neuroplastic changes occurring within the circuitry involved in motivational behavior and is thought to play a key role in certain aspects of drug addiction. There is substantial controversy about the addictive potential of modafinil, a wake-promoting drug used to treat narcolepsy that is increasingly being used as a cognitive enhancer and has been proposed as a pharmacotherapy for cocaine dependence. Male mice were used to investigate the ability of modafinil to induce locomotor sensitization after repeated or single administration in mice. Bidirectional cross-sensitization with cocaine and modafinil-induced conditioned place preference were also evaluated. Both repeated and single exposure to moderate and high doses of modafinil produced a pronounced locomotor sensitization that cross-sensitized in a bidirectional way with cocaine. Remarkably, when cocaine and modafinil were repeatedly administered sequentially, their behavioral sensitization was additive. Supporting these behavioral sensitization data, modafinil produced a pronounced conditioned place preference in the mouse. Taken together, the present findings provide pre-clinical evidence for the addictive potential of modafinil. Our data also strongly suggest that similar neural substrates are involved in the psychomotor/rewarding effects of modafinil and cocaine.
Keywords Addiction
behavioral sensitization
cocaine
conditioned place preference
mice
modafinil
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundo de Apoio ao Docente e Aluno (FADA)
Associacao Fundo de Pesquisa em Psicobiologia (AFIP)
Date 2011-10-01
Published in Addiction Biology. Malden: Wiley-Blackwell, v. 16, n. 4, p. 565-579, 2011.
ISSN 1355-6215 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 565-579
Origin http://dx.doi.org/10.1111/j.1369-1600.2011.00341.x
Access rights Closed access
Type Article
Web of Science ID WOS:000295015400005
URI http://repositorio.unifesp.br/handle/11600/34128

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