A prospective study of nutrition education and oral nutritional supplementation in patients with Alzheimer's disease

A prospective study of nutrition education and oral nutritional supplementation in patients with Alzheimer's disease

Author Pivi, Glaucia A. K. Autor UNIFESP Google Scholar
Silva, Rosimeire V. da Autor UNIFESP Google Scholar
Juliano, Yara Google Scholar
Novo, Neil F. Google Scholar
Okamoto, Ivan H. Autor UNIFESP Google Scholar
Brant, Cesar Q. Autor UNIFESP Google Scholar
Bertolucci, Paulo H. F. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Santo Amaro UNISA
Abstract Background: Weight loss in patients with Alzheimer's disease (AD) is a common clinical manifestation that may have clinical significance.Objectives: To evaluate if there is a difference between nutrition education and oral nutritional supplementation on nutritional status in patients with AD.Methods: A randomized, prospective 6-month study which enrolled 90 subjects with probable AD aged 65 years or older divided into 3 groups: Control Group (CG) [n = 27], Education Group (EG) [n = 25], which participated in an education program and Supplementation Group (SG) [n = 26], which received two daily servings of oral nutritional supplementation. Subjects were assessed for anthropometric data (weight, height, BMI, TSF, AC and AMC), biochemical data (total protein, albumin, and total lymphocyte count), CDR (Clinical Dementia Rating), MMSE (Mini-mental state examination), as well as dependence during meals.Results: the SG showed a significant improvement in the following anthropometric measurements: weight (H calc = 22.12, p =< 0.001), BMI (H calc = 22.12, p =< 0.001), AC (H calc = 12.99, p =< 0.002), and AMC (H calc = 8.67, p =< 0.013) compared to the CG and EG. BMI of the EG was significantly greater compared to the CG. There were significant changes in total protein (H calc = 6.17, p =< 0.046), and total lymphocyte count in the SG compared to the other groups (H cal = 7.94, p = 0.019).Conclusion: Oral nutritional supplementation is more effective compared to nutrition education in improving nutritional status.
Keywords supplementation
nutritional education
Alzheimer's disease
Language English
Date 2011-09-26
Published in Nutrition Journal. London: Biomed Central Ltd, v. 10, 6 p., 2011.
ISSN 1475-2891 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 6
Origin http://dx.doi.org/10.1186/1475-2891-10-98
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000295834800001
URI http://repositorio.unifesp.br/handle/11600/34057

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