The role of IL-6, IL-8 and MCP-1 and their promoter polymorphisms IL-6-174GC, IL-8-251AT and MCP-1-2518AG in the risk of venous thromboembolism: A case-control study

The role of IL-6, IL-8 and MCP-1 and their promoter polymorphisms IL-6-174GC, IL-8-251AT and MCP-1-2518AG in the risk of venous thromboembolism: A case-control study

Author Matos, Marinez Farana Autor UNIFESP Google Scholar
Lourenco, Dayse M. Autor UNIFESP Google Scholar
Orikaza, Cristina M. Autor UNIFESP Google Scholar
Bajerl, Joao A. H. Autor UNIFESP Google Scholar
Noguti, Maria A. E. Autor UNIFESP Google Scholar
Morelli, Vania M. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction: Cytokines increased the risk of venous thromboembolism (VTE) in some case-control studies, but not in a prospective study. Data concerning the role of cytokines in the risk of VTE are limited. We examined in a case-control study the association of VTE and levels of interleukin (IL)-6, IL-8 and monocyte chemotactic protein-1 (MCP-1) and assessed whether promoter polymorphisms (IL-6 -174GC, IL-8 -251AT, MCP-1 -2518AG) would affect the thrombotic risk and cytokine levels.Materials and methods: the study included 119 patients (94 women) with a first event of VTE aged between 18-60 years, and 126 healthy controls (100 women) matched for age (+/- 5 years). Blood was collected >7 months after the thrombotic event. Odds ratios (ORs) were calculated per increase of cytokines levels by 1 pg/mL.Results: ORs adjusted for age and sex were 1.520 [95% Confidence Interval (CI) 1.177 - 1.962] for IL-6, 1.095 (95% CI 1.002 - 1.196) for IL-8 and 1.000 (0.988 - 1.012) for MCP-1. With additional adjustment for ethnic composition, body mass index (BMI) and high sensitive C-reactive protein (hs-CRP), risk estimates remained significant for IL-6 and became of borderline statistical significance for IL-8. Polymorphisms did not influence the thrombotic risk and the cytokine levels in study participants.Conclusion: VTE was associated with IL-6 and IL-8 levels, and for IL-6 this association was independent of BMI and hs-CRP. Thus far, a causal relationship between inflammation and VTE remains to be clarified and more prospective data are warranted. (C) 2011 Elsevier B.V. All rights reserved.
Keywords Interleukin
Polymorphism
Risk factor
Venous thromboembolism
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2005/56799-0
Date 2011-09-01
Published in Thrombosis Research. Oxford: Pergamon-Elsevier B.V., v. 128, n. 3, p. 216-220, 2011.
ISSN 0049-3848 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 216-220
Origin http://dx.doi.org/10.1016/j.thromres.2011.04.016
Access rights Closed access
Type Article
Web of Science ID WOS:000294000100004
URI http://repositorio.unifesp.br/handle/11600/34017

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