In utero exposure to air pollution lowers erythrocyte antioxidant defense and decreases weight in adult mice

In utero exposure to air pollution lowers erythrocyte antioxidant defense and decreases weight in adult mice

Author Abe, Karina Camasmie Autor UNIFESP Google Scholar
Brandao, Leticia de Campos Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Nascimento Saldiva, Paulo Hilario do Google Scholar
D'Almeida, Vania Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract In this study, we tested the influence of ambient air pollution on different phases of development of adult mice. With respect to adult weight, the animals that had spent their in utero period exposed to pollution showed less weight gain over their lifetime, as well as lower activity levels of the antioxidant enzymes catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx). Our study suggests that contact with atmospheric pollutants during the foetal period produces important changes on enzymatic erythrocyte antioxidant defense and weight in adult mice. (C) 2011 Elsevier B.V. All rights reserved.
Keywords Air pollution
Antioxidant defense
Catalase
Superoxide dismutase
Glutathione peroxidase
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Associacao Fundo Incentivo a Pesquisa (AFIP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 07/07624-9
Date 2011-09-01
Published in Environmental Toxicology and Pharmacology. Amsterdam: Elsevier B.V., v. 32, n. 2, p. 315-318, 2011.
ISSN 1382-6689 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 315-318
Origin http://dx.doi.org/10.1016/j.etap.2011.05.001
Access rights Closed access
Type Article
Web of Science ID WOS:000294936700025
URI http://repositorio.unifesp.br/handle/11600/34008

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