Association of methamidophos and sleep loss on reproductive toxicity of male mice

Association of methamidophos and sleep loss on reproductive toxicity of male mice

Author Maia, Lucas O. Autor UNIFESP Google Scholar
Dias Junior, Walter Google Scholar
Carvalho, Loraine S. Google Scholar
Jesus, Luciana R. Google Scholar
Paiva, Greice D. Google Scholar
Araujo, Paula Autor UNIFESP Google Scholar
Costa, Marcos F. O. Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mazaro-Costa, Renata Google Scholar
Institution Universidade Federal de Goiás (UFG)
Universidade Federal de São Paulo (UNIFESP)
Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
Abstract This study investigated the effects of organophosphate exposure on the male reproductive system of mice submitted to chronic sleep loss condition. Adult Swiss mice were distributed into 4 groups: control; methamidophos (MTP); sleep restriction (SR); and MTP + SR. the dose of methamidophos was 0.002 mg kg(-1) day(-1) (half of the Acceptable Daily Intake). Sleep restriction condition was 21 h day(-1) during 15 days. in relation to control group, MTP treatment induced a significant reduction of 12% on morphologically normal spermatozoa in both MTP and MTP + SR groups. in addition, the absolute and relative weights of the seminal vesicles were decreased (MTP, -34%; MTP + SR, -45%). Epididymal fat was reduced in SR groups (SR, -64%; MTP + SR, -58%). Plasma testosterone levels were significantly decreased in MTP and SR groups, and progesterone levels were increased 8 times in MTP + SR in comparison with the control group. the corticosterone levels were unaffected by MTP or SR conditions. Thus, low dose MTP exposure resulted in deleterious effects on the male reproductive system. Sleep loss associated with MTP potentiated the effect on steroidogenesis, mainly in terms of progesterone levels. (C) 2011 Elsevier B.V. All rights reserved.
Keywords Methamidophos
Organophosphate
Sleep deprivation
Reproductive toxicity
Testosterone
Progesterone
Language English
Sponsor Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
FAPEG
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
FAPEG/RD
PET-MEC/SeSU
Grant number FAPESP: 98/143030
FAPEG: Cham 01/2007
FAPEG: Cham 04/2010
Date 2011-09-01
Published in Environmental Toxicology and Pharmacology. Amsterdam: Elsevier B.V., v. 32, n. 2, p. 155-161, 2011.
ISSN 1382-6689 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 155-161
Origin http://dx.doi.org/10.1016/j.etap.2011.04.007
Access rights Closed access
Type Article
Web of Science ID WOS:000294936700006
URI http://repositorio.unifesp.br/handle/11600/34007

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