Androgen Receptor CAG Repeat Polymorphism Is Not Associated With Erectile Dysfunction Complaints, Gonadal Steroids, and Sleep Parameters: Data From a Population-Based Survey

Show simple item record

dc.contributor.author Andersen, Monica Levy [UNIFESP]
dc.contributor.author Guindalini, Camila [UNIFESP]
dc.contributor.author Santos-Silva, Rogerio [UNIFESP]
dc.contributor.author Bittencourt, Lia Rita Azeredo [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.date.accessioned 2016-01-24T14:17:08Z
dc.date.available 2016-01-24T14:17:08Z
dc.date.issued 2011-09-01
dc.identifier http://dx.doi.org/10.2164/jandrol.110.012013
dc.identifier.citation Journal of Andrology. Lawrence: Amer Soc Andrology, Inc, v. 32, n. 5, p. 524-529, 2011.
dc.identifier.issn 0196-3635
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33993
dc.description.abstract Erectile dysfunction (ED) can be affected by androgen levels, which exert their action through the androgen receptor (AR). Androgenic action has been demonstrated to inversely correlate with a polymorphic trinucleotide CAG repeat region in the AR gene. We conducted an epidemiologic study to determine the potential association between the CAG repeat polymorphism of the AR gene and ED complaints, gonadal steroids, and sleep parameters in a large population-based sample in São Paulo, Brazil. AR CAG repeat was genotyped in 79 men with ED complaints and in 340 controls. Sleep and hormonal profiles were measured in all men. There was no association between the AR CAG repeat polymorphism and ED complaints. Moreover, there was no significant correlation among free and total testosterone, estradiol, follicle-stimulating hormone, and luteinizing hormone levels, as well as sleep parameters with the CAG repeat length, when evaluating the population as a whole, as well as subdivided into ED and control groups independently. the results were not affected when the data were analyzed in quartiles, divided by the median of the sample, or after correction for population stratification. AR CAG repeat polymorphism is not associated with ED complaints, gonadal steroids, and sleep parameters in men from a population-based sample in Brazil. en
dc.description.sponsorship Associacao Fundo de Incentivo a Pesquisa and Fundo de Amparo a Pesquisa do Estado de São Paulo
dc.description.sponsorship Centro de Pesquisa, Inovacao e Difusao
dc.description.sponsorship Centro Nacional de Desenvolvimento Cientifico e Tecnologico
dc.format.extent 524-529
dc.language.iso eng
dc.publisher Amer Soc Andrology, Inc
dc.relation.ispartof Journal of Andrology
dc.rights Acesso aberto
dc.subject Hormone en
dc.subject reproductive genetics en
dc.subject testosterone en
dc.subject CAG polymorphism en
dc.subject LH en
dc.subject FSH en
dc.title Androgen Receptor CAG Repeat Polymorphism Is Not Associated With Erectile Dysfunction Complaints, Gonadal Steroids, and Sleep Parameters: Data From a Population-Based Survey en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sponsorshipID Associacao Fundo de Incentivo a Pesquisa and Fundo de Amparo a Pesquisa do Estado de São Paulo: 07/50525-1
dc.description.sponsorshipID Centro de Pesquisa, Inovacao e Difusao: 98/14303-3
dc.identifier.doi 10.2164/jandrol.110.012013
dc.description.source Web of Science
dc.identifier.wos WOS:000293551300012



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account