Androgen Receptor CAG Repeat Polymorphism Is Not Associated With Erectile Dysfunction Complaints, Gonadal Steroids, and Sleep Parameters: Data From a Population-Based Survey

Androgen Receptor CAG Repeat Polymorphism Is Not Associated With Erectile Dysfunction Complaints, Gonadal Steroids, and Sleep Parameters: Data From a Population-Based Survey

Author Andersen, Monica Levy Autor UNIFESP Google Scholar
Guindalini, Camila Autor UNIFESP Google Scholar
Santos-Silva, Rogerio Autor UNIFESP Google Scholar
Bittencourt, Lia Rita Azeredo Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Erectile dysfunction (ED) can be affected by androgen levels, which exert their action through the androgen receptor (AR). Androgenic action has been demonstrated to inversely correlate with a polymorphic trinucleotide CAG repeat region in the AR gene. We conducted an epidemiologic study to determine the potential association between the CAG repeat polymorphism of the AR gene and ED complaints, gonadal steroids, and sleep parameters in a large population-based sample in São Paulo, Brazil. AR CAG repeat was genotyped in 79 men with ED complaints and in 340 controls. Sleep and hormonal profiles were measured in all men. There was no association between the AR CAG repeat polymorphism and ED complaints. Moreover, there was no significant correlation among free and total testosterone, estradiol, follicle-stimulating hormone, and luteinizing hormone levels, as well as sleep parameters with the CAG repeat length, when evaluating the population as a whole, as well as subdivided into ED and control groups independently. the results were not affected when the data were analyzed in quartiles, divided by the median of the sample, or after correction for population stratification. AR CAG repeat polymorphism is not associated with ED complaints, gonadal steroids, and sleep parameters in men from a population-based sample in Brazil.
Keywords Hormone
reproductive genetics
testosterone
CAG polymorphism
LH
FSH
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa and Fundo de Amparo a Pesquisa do Estado de São Paulo
Centro de Pesquisa, Inovacao e Difusao
Centro Nacional de Desenvolvimento Cientifico e Tecnologico
Grant number Associacao Fundo de Incentivo a Pesquisa and Fundo de Amparo a Pesquisa do Estado de São Paulo: 07/50525-1
Centro de Pesquisa, Inovacao e Difusao: 98/14303-3
Date 2011-09-01
Published in Journal of Andrology. Lawrence: Amer Soc Andrology, Inc, v. 32, n. 5, p. 524-529, 2011.
ISSN 0196-3635 (Sherpa/Romeo, impact factor)
Publisher Amer Soc Andrology, Inc
Extent 524-529
Origin http://dx.doi.org/10.2164/jandrol.110.012013
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000293551300012
URI http://repositorio.unifesp.br/handle/11600/33993

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