Does sleep deprivation and morphine influence wound healing?

Show simple item record

dc.contributor.author Egydio, Flavia [UNIFESP]
dc.contributor.author Tomimori, Jane [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Andersen, Monica Levy [UNIFESP]
dc.date.accessioned 2016-01-24T14:17:07Z
dc.date.available 2016-01-24T14:17:07Z
dc.date.issued 2011-09-01
dc.identifier http://dx.doi.org/10.1016/j.mehy.2011.05.012
dc.identifier.citation Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 77, n. 3, p. 353-355, 2011.
dc.identifier.issn 0306-9877
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33972
dc.description.abstract The contrast between present-day sleep habits and those of the pre-industrial era are quite evident. One study recent has shown that the amount of sleep has decreased 2 h per night over the past 50 years. Such sleep curtailment, ubiquitous in the modern lifestyle, inflicts adverse repercussions upon health and well being. Investigations examining the relationship between stress and the skin have shown that different types of stress affect the healing process. Morphine is an immunosuppressive drug, and when it is used chronically, it can lead to an increased incidence of infections and a delay in the healing process. Therefore, our hypothesis is that the lack of sleep associated with chronic treatment with morphine is detrimental to the healing of the skin in the animal model we have adopted. Thus, it is important that future studies consider the paradigm of sleep curtailment when investigating the mechanisms involved in the process of skin healing in individuals who are dependent on morphine. (C) 2011 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Associacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 353-355
dc.language.iso eng
dc.publisher Churchill Livingstone
dc.relation.ispartof Medical Hypotheses
dc.rights Acesso aberto
dc.title Does sleep deprivation and morphine influence wound healing? en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Dermatol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Dermatol, BR-04024002 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 98/14303-3
dc.identifier.file WOS000295183500010.pdf
dc.identifier.doi 10.1016/j.mehy.2011.05.012
dc.description.source Web of Science
dc.identifier.wos WOS:000295183500010



File

Name: WOS000295183500010.pdf
Size: 171.5Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account