The contextual fear conditioning deficit presented by spontaneously hypertensive rats (SHR) is not improved by mood stabilizers

The contextual fear conditioning deficit presented by spontaneously hypertensive rats (SHR) is not improved by mood stabilizers

Author Calzavara, Mariana Bendlin Autor UNIFESP Google Scholar
Medrano, Wladimir Agostini Autor UNIFESP Google Scholar
Levin, Raquel Autor UNIFESP Google Scholar
Libanio, Tania Cristina Autor UNIFESP Google Scholar
Ribeiro, Rosana de Alencar Autor UNIFESP Google Scholar
Abilio, Vanessa Costhek Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objectives: We have recently reported that spontaneously hypertensive rats (SHR) present a contextual fear conditioning (CFC) deficit. This deficit is improved by antipsychotic drugs, potentiated by proschizophrenia manipulations and not altered by acute administration of carbamazepine, lamotrigine and valproic acid. Nevertheless, the effects of lithium a classical mood stabilizer or repeated treatment with these drugs were not evaluated. the main aim of the present study was to extend our previous work by investigating a possible beneficial effect of acute and/or chronic treatments with lithium or lamotrigine on the acquisition deficit of CFC presented by SHR.Methods: Rats were submitted to CFC task after an acute treatment with lithium and/or a repeated treatment with lithium and lamotrigine.Results: Our data revealed that the CFC deficit presented by SHR is not improved by acute or repeated treatment with lithium. Repeated lamotrigine treatment potentiated the deficit presented by SHR and impaired CFC in control animals (Wistar Rats).Conclusions: These data reinforce the absence of beneficial effects of mood stabilizers on the emotional context processing impairment modeled by SHR. (C) 2011 Elsevier Inc. All rights reserved.
Keywords Bipolar disorder
Contextual fear conditioning
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2011-08-15
Published in Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 35, n. 7, p. 1607-1611, 2011.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1607-1611
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000294941800011

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