Low-Intensity Pulsed Ultrasound Accelerates Healing in Rat Calcaneus Tendon Injuries

Low-Intensity Pulsed Ultrasound Accelerates Healing in Rat Calcaneus Tendon Injuries

Author Jeremias Junior, Sergio Luiz Google Scholar
Camanho, Gilberto Luis Autor UNIFESP Google Scholar
Bassit, Ana Cristina Ferreira Google Scholar
Forgas, Andrea Google Scholar
Ingham, Sheila Jean McNeill Autor UNIFESP Google Scholar
Abdalla, Rene Jorge Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract STUDY DESIGN: Controlled laboratory study.OBJECTIVE: To evaluate the effect of low-intensity therapeutic ultrasound on the murine calcaneus tendon healing process.BACKGROUND: Therapeutic ultrasound promotes formation and maturation of scar tissue.METHODS: Calcaneus tendon tenotomy and tenorrhaphy was performed on 28 Wistar rats. After the procedure, the animals were randomly divided into 2 groups. the animals in the experimental group received a 5-minute ultrasound application, once a day, at a frequency of 1 MHz, a spatial average temporal average intensity of 0.1 W/cm(2), and a spatial average intensity of 0.52 W/cm(2) at a 16-Hz frequency pulse mode (duty cycle, 20%). Data for the injured side were normalized in relation to the data from the contralateral healthy calcaneus tendon (relative values). the animals in the control group received sham treatment. After a 28-day treatment period, the animals were sacrificed and their tendons surgically removed and subjected to mechanical stress testing. the parameters analyzed were cross-sectional area (mm(2)), ultimate load (N), tensile strength (MPa), and energy absorption (mJ).RESULTS: A significant difference between groups was found for the relative values of ultimate load and tensile strength. the mean +/- SD ultimate load of the control group was -3.5% +/- 32.2% compared to 33.3% +/- 26.8% for the experimental group (P = .005). the mean tensile strength of the control group was -47.7% +/- 19.5% compared to -28.1% +/- 24.1% for the experimental group (P = .019). No significant difference was found in cross-sectional area and energy absorption.CONCLUSION: Low-intensity pulsed ultrasound produced by a conventional therapeutic ultrasound unit can positively influence the calcaneus tendon healing process in rats. J Ort hop Sports Phys Ther 2011;41(7):526-531, Epub 2 February 2011. doi:10.2519/jospt.2011.3468
Keywords biomechanical testing
physical agents
therapeutic ultrasound
Language English
Date 2011-07-01
Published in Journal of Orthopaedic & Sports Physical Therapy. Alexandria: J O S P T,, v. 41, n. 7, p. 526-531, 2011.
ISSN 0190-6011 (Sherpa/Romeo, impact factor)
Publisher J O S P T,
Extent 526-531
Origin http://dx.doi.org/10.2519/jospt.2011.3468
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000292172300009
URI http://repositorio.unifesp.br/handle/11600/33837

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