Low molecular weight heparins: Structural differentiation by spectroscopic and multivariate approaches

Low molecular weight heparins: Structural differentiation by spectroscopic and multivariate approaches

Author Lima, Marcelo Andrade de Autor UNIFESP Google Scholar
Farias, Eduardo Henrique Cunha de Autor UNIFESP Google Scholar
Rudd, Timothy R. Google Scholar
Ebner, Lyvia Ferreira Autor UNIFESP Google Scholar
Gesteira, Tarsis Ferreira Autor UNIFESP Google Scholar
Mendes, Aline Autor UNIFESP Google Scholar
Boucas, Rodrigo Ippolito Autor UNIFESP Google Scholar
Martins, João Roberto Maciel Autor UNIFESP Google Scholar
Hoppensteadt, Debra Google Scholar
Fareed, Jawed Google Scholar
Yates, Edwin A. Google Scholar
Sassaki, Guilherme L. Google Scholar
Tersariol, Ivarne Luis dos Santos Autor UNIFESP Google Scholar
Nader, Helena Bonciani Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Liverpool
Loyola Univ
Univ Fed Parana
Abstract Various branded low molecular weight heparins (LMWHs) have been used for the treatment and prevention of thrombotic for over 20 years. With the introduction of generic LMWHs and the recent events involving heparin contamination, a great deal of effort is being expended in investigating ways of monitoring and regulating this class of complex drugs. in this paper, we present the characterization of different forms of LMWHs, as well as the comparison of 5 enoxaparin copies from different manufactures. the data suggests that, while some of these drugs are structurally comparable, specific analytical methods as well as biological and pharmacological tests may be used to address their similarity, quality and potential interchangeability. the proposed approach may also be useful in comparing biosimilar and branded LMWHs. (C) 2011 Elsevier B.V. All rights reserved.
Keywords Biosimilar
Low molecular weight heparin
Nuclear magnetic resonance
Circular dichroism
Scanning UV
Principal component analysis
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2011-07-01
Published in Carbohydrate Polymers. Oxford: Elsevier B.V., v. 85, n. 4, p. 903-909, 2011.
ISSN 0144-8617 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 903-909
Origin http://dx.doi.org/10.1016/j.carbpol.2011.04.021
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000291838900026
URI http://repositorio.unifesp.br/handle/11600/33811

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