Evaluation of anti-inflammatory activity of derivatives from aerial parts of Baccharis uncinella

Evaluation of anti-inflammatory activity of derivatives from aerial parts of Baccharis uncinella

Author Zalewski, Cynthia A. Autor UNIFESP Google Scholar
Passero, Luiz Felipe D. Google Scholar
Melo, Alexis S. R. B. Google Scholar
Corbett, Carlos Eduardo P. Google Scholar
Laurenti, Marcia D. Google Scholar
Toyama, Marcos H. Google Scholar
Toyama, Daniela O. Google Scholar
Romoff, Paulete Google Scholar
Favero, Oriana A. Google Scholar
Lago, Joao Henrique G. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Estadual Paulista Julio de Mesquito Filho
Univ Presbiteriana Mackenzie
Abstract Context: Species of Baccharis exhibit antibiotic, antiseptic, and wound-healing properties, and have been used in the traditional medicine of South America for the treatment of inflammation, headaches, diabetes, and hepatobiliary disorders.Objective: To investigate the anti-inflammatory activity of organic phases from EtOH extract of the aerial parts of Baccharis uncinella DC (Asteraceae).Materials and methods: the crude EtOH extract from the aerial parts of B. uncinella was subjected to partition procedures and the corresponding CH(2)Cl(2) and EtOAc phases were subjected to several chromatographic separation procedures. Thus, these phases and their purified compounds were assayed for evaluation of anti-inflammatory activity.Results: the CH(2)Cl(2) phase from EtOH extract from B. uncinella contained two triterpenoids (oleanolic and ursolic acids) and one flavonoid (pectolinaringenin), whereas the respective EtOAc phase showed to be composed mainly by two phenylpropanoid derivatives (caffeic and ferulic acids). the CH(2)Cl(2) and EtOAc phases as well as their isolated compounds exhibited anti-inflammatory effects against inflammatory reactions induced by phospholipase A2 (from Crotalus durissus terrificus venom) and by carrageenan.Discussion and conclusion: the results suggested that the components obtained from partition phases of EtOH extract of B. uncinella could represent lead molecules for the development of anti-inflammatory agents. Additionally, the results confirmed the use of Baccharis genus in the traditional medicine of South America for the treatment of inflammation and other heath disorders. To date, the present work describes for the first time the anti-inflammatory effects of compounds isolated from B. uncinella.
Keywords Secretory phospholipase A2 (sPLA2)
anti-inflammatory
triterpenes
phenolic compounds
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
MackPesquisa
LIM-50 HC-FMUSP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2011-06-01
Published in Pharmaceutical Biology. London: Informa Healthcare, v. 49, n. 6, p. 602-607, 2011.
ISSN 1388-0209 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 602-607
Origin http://dx.doi.org/10.3109/13880209.2010.537828
Access rights Closed access
Type Article
Web of Science ID WOS:000290404200008
URI http://repositorio.unifesp.br/handle/11600/33794

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