Repetitive transcranial magnetic stimulation reduces cortisol concentrations in bulimic disorders

Repetitive transcranial magnetic stimulation reduces cortisol concentrations in bulimic disorders

Author Claudino, A. M. Autor UNIFESP Google Scholar
Van den Eynde, F. Google Scholar
Stahl, D. Google Scholar
Dew, T. Google Scholar
Andiappan, M. Google Scholar
Kalthoff, J. Google Scholar
Schmidt, U. Google Scholar
Campbell, I. C. Google Scholar
Institution Kings Coll London
Universidade Federal de São Paulo (UNIFESP)
Kings Coll NHS Trust
Abstract Background. in people with bulimic eating disorders, exposure to high-calorie foods can result in increases in food craving, raised subjective stress and salivary cortisol concentrations. This cue-induced food craving can be reduced by repetitive transcranial magnetic stimulation (rTMS). We investigated whether rTMS has a similar effect on salivary cortisol concentrations, a measure of hypothalamic-pituitary-adrenal axis (HPAA) activity.Method. We enrolled twenty-two female participants who took part in a double-blind randomized sham-controlled trial on the effects of rTMS on food craving. Per group, eleven participants were randomized to the real or sham rTMS condition. the intervention consisted of one session of high-frequency rTMS delivered to the left dorsolateral prefrontal cortex (DLPFC). Salivary cortisol concentrations were assessed at four time points throughout the 90-min trial. To investigate differences in post-rTMS concentrations between the real and sham rTMS groups, a random-effects model including the pre-rTMS cortisol concentrations as covariates was used.Results. Salivary cortisol concentrations following real rTMS were significantly lower compared with those following sham rTMS. in this sample, there was also a trend for real rTMS to reduce food craving more than sham rTMS.Conclusions. These results suggest that rTMS applied to the left DLPFC alters HPAA activity in people with a bulimic disorder.
Keywords Binge eating
craving
eating disorders
hypothalamic-pituitary-adrenal axis
repetitive transcranial magnetic stimulation
salivary cortisol
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
National Institute for Health Research (NIHR) Specialist Biomedical Research Centre
Date 2011-06-01
Published in Psychological Medicine. New York: Cambridge Univ Press, v. 41, n. 6, p. 1329-1336, 2011.
ISSN 0033-2917 (Sherpa/Romeo, impact factor)
Publisher Cambridge Univ Press
Extent 1329-1336
Origin http://dx.doi.org/10.1017/S0033291710001881
Access rights Closed access
Type Article
Web of Science ID WOS:000290221200021
URI http://repositorio.unifesp.br/handle/11600/33768

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