Clinical correlates of olfactory dysfunction in spinocerebellar ataxia type 3

Clinical correlates of olfactory dysfunction in spinocerebellar ataxia type 3

Author Braga-Neto, P. Autor UNIFESP Google Scholar
Felicio, A. C. Autor UNIFESP Google Scholar
Pedroso, J. L. Autor UNIFESP Google Scholar
Dutra, L. A. Autor UNIFESP Google Scholar
Bertolucci, P. H. F. Autor UNIFESP Google Scholar
Gabbai, Alberto Alain Autor UNIFESP Google Scholar
Barsottini, O. G. P. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Olfactory dysfunction is a very common and early sign in neurodegenerative disorders, but few data are already available in hereditary ataxias. Our aim was to evaluate the sense of smell in patients with molecular-proven spinocerebellar ataxia type 3 (SCA3). Forty-one patients with SCA3 and 46 control subjects were studied. the sense of smell was tested using the Sniffin's Sticks (SS-16). We also evaluated Mini-Mental State Examination (MMSE) and non-cerebellar symptoms, such as parkinsonism, dystonia, and restless legs syndrome (RLS). the SCA3 group had significantly lower SS-16 scores than controls (11.5 +/- 2.4 vs 12.8 +/- 1.5, p = 0.003). Multiple linear regression analyses, controlling for age, sex, education, cigarette smoking, and MMSE scores, showed that SCA3 (p = 0.021), sex (p = 0.003) and MMSE scores (p = 0.002) had significant regression coefficients. All the variables taken together were significantly associated with the SS-16 scores (p <= 0.001). Although MMSE scores and female sex were stronger predictors of the SS-16 scores than SCA3. subjects with SCA3 had lower scores on the SS-16, regardless of sex or MMSE scores. Additionally, MMSE scores, sex and presence of RLS were the best predictors of SS-16 scores. Overall, our results strengthen that the sense of smell is significantly reduced in patients with SCA3 and that sex, MMSE scores and RLS also influence the SS-16 scores. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
Keywords Spinocerebellar ataxia type 3
Machado Joseph disease
Olfactory dysfunction
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2011-06-01
Published in Parkinsonism & Related Disorders. Oxford: Elsevier B.V., v. 17, n. 5, p. 353-356, 2011.
ISSN 1353-8020 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 353-356
Origin http://dx.doi.org/10.1016/j.parkreldis.2011.02.004
Access rights Closed access
Type Article
Web of Science ID WOS:000292487200010
URI http://repositorio.unifesp.br/handle/11600/33764

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