Rubus rosaefolius Extract as a Natural Preservative Candidate in Topical Formulations

Rubus rosaefolius Extract as a Natural Preservative Candidate in Topical Formulations

Author Ostrosky, Elissa Arantes Google Scholar
Marcondes, Elda Maria Cecilio Google Scholar
Nishikawa, Suzana de Oliveira Google Scholar
Lopes, Patricia Santos Autor UNIFESP Google Scholar
Varca, Gustavo Henrique Costa Google Scholar
Pinto, Terezinha de Jesus Andreoli Google Scholar
Consiglieri, T. Google Scholar
Baby, Andre Rolim Google Scholar
Velasco, Maria Valeria Robles Google Scholar
Kaneko, Telma Mary Google Scholar
Institution Universidade de São Paulo (USP)
Univ Sorocaba
Universidade Federal de São Paulo (UNIFESP)
Abstract Even though the synthetic preservatives may offer a high antimicrobial efficacy, they are commonly related to adverse reactions and regarded as having potentially harmful effects caused by chronic consumption. the development of natural preservatives provides a way of reducing the amount of synthetic preservatives normally used in pharmaceutical and cosmetic preparations. in addition, these agents have less toxic effects and represent a possible natural and safer alternative of the preservatives. the purpose of this research was to evaluate the Rubus rosaefolius Smith extract efficiency as a natural preservative in base formulations. of the extract, 0.2% (w/w) was assayed for its effectiveness of antimicrobial protection in two different base formulations (emulsion and gel). the microbial challenge test was performed following the standard procedures proposed by the United States Pharmacopoeia 33nd, European Pharmacopoeia 6th, Japanese Pharmacopoeia 15th, and the Cosmetics, Toiletries, and Fragrance Association using standardized microorganisms. the results demonstrated that R. rosaefolius extract at the studied concentration reduced the bacterial inocula, satisfying the criterion in all formulations, even though it was not able to present an effective preservative behavior against fungi. Thus, the investigation of new natural substances with preservative properties that could be applied in pharmaceutical and cosmetic products is relevant due to the possibility of substituting or decreasing the concentration of synthetic preservatives, providing a way for the development of safer formulas for the use of consumers.
Keywords antimicrobial effectiveness testing
challenge test
natural preservative
Rubus rosaefolius Sm.
topical formulations
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Natura Inovacao e Tecnologia de Produtos LTDA
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2011-06-01
Published in Aaps Pharmscitech. New York: Springer, v. 12, n. 2, p. 732-737, 2011.
ISSN 1530-9932 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 732-737
Origin http://dx.doi.org/10.1208/s12249-011-9635-9
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000292688700033
URI http://repositorio.unifesp.br/handle/11600/33729

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