Lipids an Age-related Macular Degeneration

Show simple item record Kishan, Amar U. Modjtahedi, Bobeck S. Martins, Elisabeth N. [UNIFESP] Modjtahedi, Sara P. Morse, Lawrence S. 2016-01-24T14:16:43Z 2016-01-24T14:16:43Z 2011-05-01
dc.identifier.citation Survey of Ophthalmology. New York: Elsevier B.V., v. 56, n. 3, p. 195-213, 2011.
dc.identifier.issn 0039-6257
dc.description.abstract Given the considerable public health burden imposed by age-related macular degeneration (AMD), much effort has been directed towards elucidating principles of pathogenesis in order to identify risk factors and develop preventive measures and treatments. Together with epidemiological evidence linking cardiovascular risk factors with AMD risk and basic science work examining the role of lipid metabolism in AMD, numerous human studies have assayed a potential relationship between dietary lipids and the development of AMD. We examine the evidence for a role for lipid metabolism in AMD, highlighting key basic biochemical principles, work in animal models, and relevant human studies. the topics of lipoprotein modulation and omega-3 fatty acid intake receive special attention from both a basic science and clinical study standpoint. the evidence suggests that consumption of omega-3 fatty acids, perhaps in concert with antioxidants, may constitute a rational preventative strategy against AMD development, though, absent an appropriately developed double-blind, randomized control trial, insufficient data exist to recommend implementation in the clinical setting at this time. (Surv Ophthalmol 56:195-213, 2011. (C) 2011 Elsevier Inc. All rights reserved.) en
dc.format.extent 195-213
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Survey of Ophthalmology
dc.rights Acesso restrito
dc.subject Age-related macular degeneration en
dc.subject cholesterol en
dc.subject eicosapentaenoic acid en
dc.subject diet en
dc.subject docosahexaenoic acid en
dc.subject human en
dc.subject lipids en
dc.subject metabolism en
dc.subject omega-3 en
dc.subject statin en
dc.title Lipids an Age-related Macular Degeneration en
dc.type Resenha
dc.contributor.institution UC Davis Eye Ctr
dc.contributor.institution Harvard Univ
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation UC Davis Eye Ctr, Sacramento, CA 95817 USA
dc.description.affiliation Harvard Univ, Sch Med, Boston, MA USA
dc.description.affiliation Universidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.identifier.doi 10.1016/j.survophthal.2010.08.008
dc.description.source Web of Science
dc.identifier.wos WOS:000290187600003


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