Visceral fat decreased by long-term interdisciplinary lifestyle therapy correlated positively with interleukin-6 and tumor necrosis factor-alpha and negatively with adiponectin levels in obese adolescents

Visceral fat decreased by long-term interdisciplinary lifestyle therapy correlated positively with interleukin-6 and tumor necrosis factor-alpha and negatively with adiponectin levels in obese adolescents

Author Lira, Fabio Santos de Autor UNIFESP Google Scholar
Rosa Neto, José Cesar Autor UNIFESP Google Scholar
Santos, Ronaldo Vagner Thomatieli dos Autor UNIFESP Google Scholar
Venancio, Daniel Paulino Autor UNIFESP Google Scholar
Carnier, June Autor UNIFESP Google Scholar
Sanches, Priscila de Lima Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Piano, Aline de Autor UNIFESP Google Scholar
Tock, Lian Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The purpose of this study was to assess the level of cytokine expression in correlation with visceral and subcutaneous fat in obese adolescents admitted to long-term interdisciplinary weight loss therapy. the study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (18, aged 15-19 years) with body mass indexes greater than the 95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. Visceral and subcutaneous fat was analyzed by ultrasonography. Blood samples were collected to analyze tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-10 (IL-10), and adiponectin concentrations that were measured by enzyme-linked immunosorbent assay. the most important finding in the present investigation is that the long-term interdisciplinary lifestyle therapy decreased visceral fat. Positive correlations between IL-6 levels and visceral fat (r = 0.42, P < .02) and TNF-alpha levels and visceral fat (r = 0.40, P < .05) were observed. Negative correlations between TNF-alpha levels and subcutaneous fat (r = -0.46, P < .01) and adiponectin levels and subcutaneous fat (r = -0.43, P < .03) were also observed. in addition, we found a positive correlation between TNF-alpha levels and the visceral to subcutaneous fat ratio (r = 0.42, P < .02) and a negative correlation between adiponectin level and the visceral to subcutaneous fat ratio (r = -0.69, P < .001). Despite the limitation of sample size, our results indicate that the observed massive weight loss (mainly visceral fat) was highly correlated with a decreased inflammatory state, suggesting that the interdisciplinary therapy was effective in decreasing inflammatory markers. (C) 2011 Elsevier Inc. All rights reserved.
Language English
Sponsor AFIP
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
CENESP
FADA
UNIFESP-EPM
CEPE-GEO
Grant number FAPESP: 2006/00684-3
FAPESP: 2008/53069-0
FAPESP: 9814303-3
Date 2011-03-01
Published in Metabolism-clinical and Experimental. Philadelphia: W B Saunders Co-Elsevier Inc, v. 60, n. 3, p. 359-365, 2011.
ISSN 0026-0495 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 359-365
Origin https://dx.doi.org/10.1016/j.metabol.2010.02.017
Access rights Closed access
Type Article
Web of Science ID WOS:000287894700005
URI https://repositorio.unifesp.br/handle/11600/33531

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