Gingival Overgrowth Among Patients Medicated With Cyclosporin A and Tacrolimus Undergoing Renal Transplantation: A Prospective Study

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dc.contributor.author Paixao, Caroline G.
dc.contributor.author Sekiguchi, Ricardo T.
dc.contributor.author Saraiva, Luciana
dc.contributor.author Pannuti, Claudio M.
dc.contributor.author Silva, Hello T. [UNIFESP]
dc.contributor.author Medina-Pestana, Jose O. [UNIFESP]
dc.contributor.author Romito, Giuseppe A.
dc.date.accessioned 2016-01-24T14:06:10Z
dc.date.available 2016-01-24T14:06:10Z
dc.date.issued 2011-02-01
dc.identifier http://dx.doi.org/10.1902/jop.2010.100368
dc.identifier.citation Journal of Periodontology. Chicago: Amer Acad Periodontology, v. 82, n. 2, p. 251-258, 2011.
dc.identifier.issn 0022-3492
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33452
dc.description.abstract Background: the aim of this study is to make a longitudinal evaluation of the incidence and severity of gingival overgrowth (GO) induced by immunosuppressive agents, such as tacrolimus (Tcr) and cyclosporin A (CsA), in the absence of calcium channel blockers in patients undergoing renal transplantation (RT).Methods: This longitudinal study is conducted in 49 patients with RT who were divided into a CsA group (n = 25) and Tcr group (n = 24). the individuals were assessed at four time intervals: before transplant and 30, 90, and 180 days after RTs. Demographic data and periodontal clinical parameters (plaque index, cemento-enamel junction to the gingival margin, probing depth, clinical attachment level, bleeding on probing [BOP], and GO) were collected at all time intervals.Results: the mean GO index was significantly lower in the Tcr group compared to the CsA group after 30 (P = 0.03), 90 (P = 0.004), and 180 (P = 0.01) days of immunosuppressive therapy. One hundred eighty days after RTs, a clinically significant GO was observed in 20.0% of individuals in the CsA group and 8.3% of individuals in the Tcr group. However, this difference was not statistically significant (P = 0.41). There was a reduction in periodontal clinical parameters regarding the time of immunosuppressive therapy for PI and BOP (P<0.001) in both groups.Conclusion: Although there was no statistical difference in the incidences of clinically significant GO after 180 days of immunosuppressive therapy, it was observed that GO occurred later in the Tcr group, and the severity of GO in this group was lower than in patients who used CsA. J Periodontol 2011;82:251-258. en
dc.description.sponsorship Foundations that Support Research in the State of São Paulo, São Paulo, S.P., Brazil
dc.format.extent 251-258
dc.language.iso eng
dc.publisher Amer Acad Periodontology
dc.relation.ispartof Journal of Periodontology
dc.rights Acesso restrito
dc.subject Cyclosporine en
dc.subject gingival overgrowth en
dc.subject tacrolimus en
dc.title Gingival Overgrowth Among Patients Medicated With Cyclosporin A and Tacrolimus Undergoing Renal Transplantation: A Prospective Study en
dc.type Artigo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ São Paulo, Sch Dent, Dept Stomatol, Div Periodont, BR-05508 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Paulista Med Sch, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Paulista Med Sch, Div Nephrol, São Paulo, Brazil
dc.description.sponsorshipID Foundations that Support Research in the State of São Paulo, São Paulo, S.P., Brazil: 04/13167-1
dc.identifier.doi 10.1902/jop.2010.100368
dc.description.source Web of Science
dc.identifier.wos WOS:000287008800009



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