Inflammatory Mediators Gene Polymorphisms in Preeclampsia

Inflammatory Mediators Gene Polymorphisms in Preeclampsia

Author Franchim, Camila Sommerauer Autor UNIFESP Google Scholar
Sass, Nelson Autor UNIFESP Google Scholar
Mattar, Rosiane Autor UNIFESP Google Scholar
Pendeloski, Karen P. T. Autor UNIFESP Google Scholar
Lin, Lawrence Hsu Autor UNIFESP Google Scholar
Torloni, Maria R. Autor UNIFESP Google Scholar
Daher, Silvia Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective. To assess a possible relation between proinflammatory mediators (IL-1R1, IL-12, IL-18, TLR-2, and TLR-4) gene polymorphisms and preeclampsia (PE). Methods. Genotyping was performed on 109 preeclamptic patients and 174 healthy fertile women with at least two previous successful pregnancies (controls). chi(2) or Fisher's exact test were used to compare genotype frequencies. the control group included 174 pregnant women matched by race to the study group. Results. Genotypic and allelic distributions for all six polymorphisms were similar between the study and control groups. IL-1R1 (PstI, rs2234650): p = 0.82; IL-12 (+1188, rs3212227): p = 0.93; IL-18 (-137, rs187238): p = 0.74; IL-18 (-607, rs1946519): p = 0.22; TLR-2 (+2258, rs5743708): p = 0.97; and TLR-4 (+896, rs4986790): p = 0.23. Conclusion. the analyzed gene polymorphisms are not associated with PE.
Keywords Cytokines
Inflammatory mediators
Genetic Polymorphism
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 07/56791-5
FAPESP: 07/57446-0
Date 2011-01-01
Published in Hypertension in Pregnancy. London: Informa Healthcare, v. 30, n. 3, p. 338-346, 2011.
ISSN 1064-1955 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 338-346
Access rights Closed access
Type Article
Web of Science ID WOS:000292566200010

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