Cognitive dysfunction in post-traumatic obsessive-compulsive disorder

Cognitive dysfunction in post-traumatic obsessive-compulsive disorder

Author Borges, Manuela C. Google Scholar
Braga, Daniela T. Google Scholar
Iego, Sandro Google Scholar
D'Alcante, Carina C. Google Scholar
Sidrim, Ilduara Google Scholar
Machado, Maria Cristiana Google Scholar
Pinto, Paula S. P. Google Scholar
Cordioli, Aristides V. Google Scholar
Rosario, Maria Conceicao do Autor UNIFESP Google Scholar
Petribu, Katia Google Scholar
Mendlowicz, Mauro V. Google Scholar
Mari, Jair J. Autor UNIFESP Google Scholar
Miguel, Euripedes C. Google Scholar
Fontenelle, Leonardo F. Google Scholar
Institution Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal Fluminense (UFF)
Univ Fed Rio Grande do Sul
Universidade Federal da Bahia (UFBA)
Universidade de São Paulo (USP)
Univ Pernambuco
Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To investigate whether patients who develop obsessive-compulsive disorder (OCD) after posttraumatic stress disorder, i.e. post-traumatic OCD (PsT-OCD), display a distinctive neurocognitive pattern of dysfunction.Methods: Patients with PsT-OCD (n = 16), pre-traumatic OCD (PrT-OCD) (n = 18), non-traumatic OCD (NonT-OCD) (n = 67) and healthy controls (n = 17) had their performance compared on the following neuropsychological tests: the Wisconsin Card Sorting Test, the Iowa Gambling Task, the Wechsler Memory Scale Logical Memory, the Brief Visual Memory Test - Revised, and the Wechsler Abbreviated Scale for Intelligence.Results: Patients with OCD, as a group, were characterized by poor set-shifting abilities and impaired verbal and visuospatial memories. Impaired set-shifting abilities were found to correlate with the severity of obsessive-compulsive symptoms in all groups of patients with OCD, with the exception of PsT-OCD. Only patients with PsT-OCD were characterized by impaired visuospatial recognition, which was found to correlate with poor set-shifting abilities in this particular group of patients, but not in individuals with other types of OCD or in healthy controls.Conclusions: Our study suggests that PsT-OCD is associated with a distinctive pattern of neurocognitive dysfunction, thus providing support for a different subtype of OCD.
Keywords obsessive-compulsive disorder
trauma
post-traumatic stress disorder
neuropsychiatry
Language English
Date 2011-01-01
Published in Australian and New Zealand Journal of Psychiatry. New York: Informa Healthcare, v. 45, n. 1, p. 76-85, 2011.
ISSN 0004-8674 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 76-85
Origin http://dx.doi.org/10.3109/00048674.2010.527822
Access rights Closed access
Type Article
Web of Science ID WOS:000285507300008
URI http://repositorio.unifesp.br/handle/11600/33343

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