Is Neuropathy Involved with Restless Legs Syndrome in Machado-Joseph Disease?

Is Neuropathy Involved with Restless Legs Syndrome in Machado-Joseph Disease?

Author Pedroso, Jose Luiz Autor UNIFESP Google Scholar
Escorcio Bezerra, Marcio Luiz Autor UNIFESP Google Scholar
Braga-Neto, Pedro Autor UNIFESP Google Scholar
Pinheiro, Denise Spinola Autor UNIFESP Google Scholar
Minett, Thais Autor UNIFESP Google Scholar
Prado, Gilmar Fernandes do Autor UNIFESP Google Scholar
Manzano, Gilberto Mastrocola Autor UNIFESP Google Scholar
Barsottini, Orlando Graziani Povoas Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To evaluate a group of spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease (MJD) (SCA3/MJD) patients and assess whether there is an association between neuropathy and serum ferritin levels and restless legs syndrome (RLS). Methods: Twenty-six SCA3/MJD patients underwent electromyography studies to check for neuropathy. Their serum ferritin levels were measured as well. These findings were evaluated based on the presence or not of RLS and its severity. Results: the proportion of neuropathy in the RLS group was not significantly higher compared to the non-RLS group (23 vs. 15%, Fisher's exact test, p = 1.000). Furthermore, no association was found between RLS and ferritin levels. Conclusion: We found no correlation between neuropathy or ferritin levels and RLS in SCA3/MJD patients. Copyright (C) 2011 S. Karger AG, Basel
Keywords Spinocerebellar ataxia type 3
Machado-Joseph disease
Restless legs syndrome
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2011-01-01
Published in European Neurology. Basel: Karger, v. 66, n. 4, p. 200-203, 2011.
ISSN 0014-3022 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 200-203
Access rights Closed access
Type Article
Web of Science ID WOS:000295363700004

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