Absence of Association between TNF-alpha Polymorphism and Cerebral Large-Vessel Abnormalities in Adults with Sickle Cell Anemia

Absence of Association between TNF-alpha Polymorphism and Cerebral Large-Vessel Abnormalities in Adults with Sickle Cell Anemia

Author Vicari, Perla Autor UNIFESP Google Scholar
Silva, Gisele Sampaio Autor UNIFESP Google Scholar
Elko Nogutti, Maria Aparecida Autor UNIFESP Google Scholar
Moreira Neto, Faustino Autor UNIFESP Google Scholar
Santos, Normelia Jesus dos Autor UNIFESP Google Scholar
Massaro, Ayrton Roberto Autor UNIFESP Google Scholar
Figueiredo, Maria Stella Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Stroke is a serious complication of sickle cell anemia (SCA) affecting children and adults. Recent reports suggested that tumor necrosis factor-alpha (TNF-alpha) (-308) polymorphism is an important risk factor for stroke in children with SCA. the role of TNF-alpha polymorphism in the frequency of brain magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) abnormalities in adults with SCA is still uncertain. Our objective was to evaluate the frequency of INF-alpha polymorphism in adults with SCA and to correlate it to brain MRI and MRA findings. TNF-alpha (-308) polymorphism was determined in 49 adults with SCA. All subjects were evaluated with brain MRI/MRA to establish the presence of intracranial abnormalities. Thirty-three (67.3%) had abnormal brain MRA scans, 8 (16.3%) had intracranial stenosis and 29 (59.2%) showed arterial tortuosity. Forty-one (83.7%) had the GG genotype and 8 had the GA genotype. There was no correlation between homozygosity for G allele and MRA or MRI abnormalities. Although INF-alpha (-308) polymorphism is a potential predictor of the genetic risk for stroke in children, we found no association between the polymorphism and large vessel abnormalities in adults with SCA. Copyright (C)2010 S. Karger AG, Basel
Keywords Sickle cell disease
Stroke
Genetic polymorphism
Interleukins
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 04/04498-4
Date 2011-01-01
Published in Acta Haematologica. Basel: Karger, v. 125, n. 3, p. 141-144, 2011.
ISSN 0001-5792 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 141-144
Origin http://dx.doi.org/10.1159/000321935
Access rights Closed access
Type Article
Web of Science ID WOS:000289018200009
URI http://repositorio.unifesp.br/handle/11600/33328

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